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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
23.33
Human Site:
S90
Identified Species:
36.67
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
S90
S
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
R96
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
S101
S
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
Dog
Lupus familis
XP_546627
413
46697
S104
S
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
S88
S
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
Rat
Rattus norvegicus
Q4KSH7
419
47517
I108
K
Q
T
G
Y
L
T
I
G
G
Q
R
Y
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
R98
P
S
G
L
I
M
A
R
K
L
I
H
L
E
I
Frog
Xenopus laevis
Q07192
446
50082
S137
S
S
G
K
L
K
L
S
P
E
Q
H
W
D
F
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
Y65
R
D
L
D
S
K
A
Y
V
T
I
G
E
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
G110
G
K
L
Q
F
G
E
G
G
A
N
T
H
T
F
Honey Bee
Apis mellifera
XP_394054
436
49631
S125
S
T
G
K
L
Q
L
S
P
N
A
V
Y
D
F
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
Q67
T
F
S
S
A
N
L
Q
D
L
G
A
I
G
N
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
F86
P
I
V
Q
T
Y
E
F
T
S
A
D
L
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
E60
S
R
Q
S
D
S
K
E
L
D
F
E
I
T
A
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
S348
S
S
K
G
I
D
F
S
N
G
S
S
S
R
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
20
100
100
N.A.
100
6.6
N.A.
N.A.
20
93.3
6.6
N.A.
6.6
53.3
0
0
P-Site Similarity:
100
33.3
100
100
N.A.
100
13.3
N.A.
N.A.
33.3
100
6.6
N.A.
13.3
80
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
20
0
0
7
14
7
0
0
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
7
7
7
0
0
7
7
0
7
0
40
7
% D
% Glu:
0
0
0
0
0
0
14
7
0
34
0
7
7
20
0
% E
% Phe:
0
7
0
0
7
0
7
7
0
0
7
0
0
0
47
% F
% Gly:
7
0
54
14
0
7
0
7
14
14
7
7
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
47
7
0
0
% H
% Ile:
0
7
0
0
14
0
27
7
0
0
20
0
14
0
20
% I
% Lys:
7
7
7
40
0
40
7
0
14
0
0
0
0
7
0
% K
% Leu:
0
0
14
14
40
7
20
0
7
20
0
0
20
0
0
% L
% Met:
0
0
0
0
0
14
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
0
7
7
7
0
0
0
14
% N
% Pro:
20
0
0
0
0
0
0
0
40
0
0
0
0
0
0
% P
% Gln:
0
7
7
14
0
7
0
7
0
0
40
0
0
7
0
% Q
% Arg:
7
7
0
0
0
0
0
14
0
0
0
7
0
7
0
% R
% Ser:
54
54
7
14
7
7
0
47
0
7
7
7
7
0
0
% S
% Thr:
7
7
7
0
7
0
7
0
7
7
0
7
0
14
0
% T
% Val:
0
0
7
0
7
0
0
0
7
0
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
34
0
0
% W
% Tyr:
0
0
0
0
7
7
0
7
0
0
0
0
14
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _