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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
24.85
Human Site:
S80
Identified Species:
39.05
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
S80
I
E
R
L
R
T
H
S
I
E
S
S
G
K
L
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
S86
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
S91
I
E
R
L
R
T
H
S
I
E
S
S
G
K
L
Dog
Lupus familis
XP_546627
413
46697
S94
I
E
R
L
R
T
H
S
I
E
S
S
G
K
L
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
S78
I
E
R
L
R
T
H
S
I
E
S
S
G
K
L
Rat
Rattus norvegicus
Q4KSH7
419
47517
E98
E
I
D
Q
K
L
Q
E
I
M
K
Q
T
G
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
Q88
G
G
V
V
T
K
V
Q
H
K
P
S
G
L
I
Frog
Xenopus laevis
Q07192
446
50082
S127
L
E
R
L
R
T
H
S
I
E
S
S
G
K
L
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
T55
E
K
P
A
P
A
P
T
P
P
R
D
L
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
Q100
H
R
E
R
I
R
Q
Q
A
C
G
K
L
Q
F
Honey Bee
Apis mellifera
XP_394054
436
49631
S115
D
K
L
R
M
C
Q
S
M
Q
S
T
G
K
L
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
H57
L
K
Y
P
D
D
E
H
L
Y
T
F
S
S
A
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
T76
Y
E
G
L
E
Y
F
T
V
S
P
I
V
Q
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
E50
G
L
R
L
T
S
D
E
K
Q
S
R
Q
S
D
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
L338
S
L
N
F
A
G
K
L
S
L
S
S
K
G
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
20
100
100
N.A.
100
6.6
N.A.
N.A.
13.3
93.3
0
N.A.
0
33.3
0
13.3
P-Site Similarity:
100
40
100
100
N.A.
100
13.3
N.A.
N.A.
33.3
100
13.3
N.A.
6.6
60
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
7
7
0
0
7
0
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% C
% Asp:
7
0
7
0
7
7
7
0
0
0
0
7
0
7
7
% D
% Glu:
14
40
7
0
7
0
7
14
0
34
0
0
0
0
0
% E
% Phe:
0
0
0
7
7
0
7
0
0
0
0
7
0
0
7
% F
% Gly:
20
14
7
0
0
7
0
0
0
0
7
0
54
14
0
% G
% His:
7
0
0
0
0
0
34
7
14
0
0
0
0
0
0
% H
% Ile:
27
7
0
0
7
0
0
0
40
0
0
7
0
0
14
% I
% Lys:
0
20
0
0
7
14
7
0
7
14
7
7
7
40
0
% K
% Leu:
14
14
7
47
0
7
0
7
7
7
0
0
14
14
40
% L
% Met:
0
0
0
0
7
0
0
0
7
7
0
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
7
7
7
0
7
0
7
7
20
0
0
0
0
% P
% Gln:
0
0
0
7
0
0
20
14
0
14
0
7
7
14
0
% Q
% Arg:
0
7
40
14
34
7
0
0
0
0
7
7
0
0
0
% R
% Ser:
7
0
0
0
0
7
0
47
7
7
54
54
7
14
7
% S
% Thr:
0
0
0
0
14
34
0
14
0
0
7
7
7
0
7
% T
% Val:
0
0
14
14
0
0
14
0
7
0
0
0
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
7
0
0
7
0
0
0
7
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _