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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
7.58
Human Site:
S36
Identified Species:
11.9
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
S36
P
G
H
P
A
V
S
S
M
Q
G
K
R
K
A
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
D43
K
L
E
E
L
E
L
D
E
Q
Q
R
K
R
L
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
S36
P
G
H
P
A
V
S
S
M
Q
G
F
Q
I
N
Dog
Lupus familis
XP_546627
413
46697
H38
P
E
S
R
S
G
S
H
S
Q
E
L
S
A
L
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
Q36
H
P
A
V
S
S
M
Q
G
K
R
K
A
L
K
Rat
Rattus norvegicus
Q4KSH7
419
47517
P36
D
L
N
L
D
I
S
P
Q
R
P
R
P
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
K37
A
N
L
V
D
L
Q
K
K
L
E
E
L
E
L
Frog
Xenopus laevis
Q07192
446
50082
S48
Q
Q
H
S
T
V
N
S
M
Q
G
K
R
K
A
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
S15
E
S
K
V
F
C
D
S
P
S
P
N
P
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
R60
S
Q
H
N
H
V
T
R
C
F
G
A
Q
Q
P
Honey Bee
Apis mellifera
XP_394054
436
49631
E36
S
I
N
D
V
Q
N
E
M
S
E
K
R
R
Q
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
P17
R
N
S
M
S
L
R
P
T
S
L
S
T
R
P
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
E36
N
L
L
E
K
Q
P
E
I
N
N
G
P
S
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
Q10
K
I
K
S
N
L
K
Q
L
K
L
S
V
P
A
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
A56
D
L
H
A
R
V
K
A
F
Q
E
Q
R
A
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
6.6
73.3
20
N.A.
6.6
6.6
N.A.
N.A.
0
66.6
13.3
N.A.
20
20
0
0
P-Site Similarity:
100
26.6
80
26.6
N.A.
20
33.3
N.A.
N.A.
20
73.3
13.3
N.A.
40
40
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
7
14
0
0
7
0
0
0
7
7
14
20
% A
% Cys:
0
0
0
0
0
7
0
0
7
0
0
0
0
0
0
% C
% Asp:
14
0
0
7
14
0
7
7
0
0
0
0
0
0
0
% D
% Glu:
7
7
7
14
0
7
0
14
7
0
27
7
0
7
0
% E
% Phe:
0
0
0
0
7
0
0
0
7
7
0
7
0
0
0
% F
% Gly:
0
14
0
0
0
7
0
0
7
0
27
7
0
0
7
% G
% His:
7
0
34
0
7
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
14
0
0
0
7
0
0
7
0
0
0
0
7
0
% I
% Lys:
14
0
14
0
7
0
14
7
7
14
0
27
7
20
7
% K
% Leu:
0
27
14
7
7
20
7
0
7
7
14
7
7
7
34
% L
% Met:
0
0
0
7
0
0
7
0
27
0
0
0
0
0
0
% M
% Asn:
7
14
14
7
7
0
14
0
0
7
7
7
0
0
7
% N
% Pro:
20
7
0
14
0
0
7
14
7
0
14
0
20
7
14
% P
% Gln:
7
14
0
0
0
14
7
14
7
40
7
7
14
7
14
% Q
% Arg:
7
0
0
7
7
0
7
7
0
7
7
14
27
20
0
% R
% Ser:
14
7
14
14
20
7
27
27
7
20
0
14
7
7
0
% S
% Thr:
0
0
0
0
7
0
7
0
7
0
0
0
7
7
0
% T
% Val:
0
0
0
20
7
34
0
0
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _