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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
35.15
Human Site:
S257
Identified Species:
55.24
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
S257
I
S
G
Q
L
V
D
S
I
A
K
T
R
D
A
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
L251
S
D
I
W
S
M
G
L
S
P
V
E
M
A
V
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
S268
I
S
G
Q
L
V
D
S
I
A
K
T
R
D
A
Dog
Lupus familis
XP_546627
413
46697
S271
I
S
G
Q
L
V
D
S
I
A
K
T
R
D
A
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
S255
I
S
G
Q
L
V
D
S
I
A
K
T
R
D
A
Rat
Rattus norvegicus
Q4KSH7
419
47517
S271
I
S
G
R
L
V
D
S
K
A
K
T
R
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
E257
S
M
G
L
S
L
V
E
L
S
I
G
R
Y
P
Frog
Xenopus laevis
Q07192
446
50082
S304
I
S
G
Q
L
V
D
S
I
A
K
T
R
D
A
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
V220
L
I
N
M
Q
G
Q
V
K
M
C
D
F
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
S277
I
S
G
Q
L
V
D
S
I
A
K
T
K
D
A
Honey Bee
Apis mellifera
XP_394054
436
49631
S292
I
S
G
Q
L
V
D
S
I
A
R
T
R
D
A
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
S222
I
C
G
Q
L
E
E
S
F
A
K
T
H
D
A
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
G241
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
S215
K
I
S
D
F
G
V
S
A
S
L
A
S
S
M
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
A513
G
V
S
G
N
L
V
A
S
L
A
K
T
N
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
0
100
100
N.A.
100
80
N.A.
N.A.
13.3
100
0
N.A.
93.3
93.3
66.6
6.6
P-Site Similarity:
100
6.6
100
100
N.A.
100
86.6
N.A.
N.A.
33.3
100
6.6
N.A.
100
100
73.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
7
7
60
7
7
0
7
67
% A
% Cys:
0
14
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
7
7
7
0
0
54
0
0
0
0
14
0
54
0
% D
% Glu:
0
0
0
0
0
7
7
7
0
0
0
7
0
0
0
% E
% Phe:
0
0
0
7
7
0
0
0
7
0
0
0
7
0
0
% F
% Gly:
7
0
67
7
7
14
7
7
0
0
0
7
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
60
14
7
0
0
7
0
0
47
0
7
0
0
7
14
% I
% Lys:
7
0
0
0
0
0
0
0
14
0
54
7
7
0
0
% K
% Leu:
14
0
0
7
60
14
0
7
7
14
7
0
0
0
0
% L
% Met:
0
7
0
7
0
7
0
0
0
7
0
0
7
0
7
% M
% Asn:
0
0
7
0
7
0
0
0
0
0
0
0
0
7
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% P
% Gln:
0
0
0
54
7
0
7
0
7
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
7
0
54
0
0
% R
% Ser:
14
54
14
0
14
0
7
67
14
14
0
0
14
14
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
60
7
0
0
% T
% Val:
0
7
0
0
0
54
20
7
0
0
14
0
0
0
7
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _