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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAPK8 All Species: 30.3
Human Site: S97 Identified Species: 60.61
UniProt: P45983 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P45983 NP_002741.1 427 48296 S97 N V F T P Q K S L E E F Q D V
Chimpanzee Pan troglodytes Q9N272 365 41989 S57 K V A I K K L S R P F Q S E I
Rhesus Macaque Macaca mulatta XP_001108865 427 48293 S97 N V F T P Q K S L E E F Q D V
Dog Lupus familis XP_534943 427 48266 S97 N V F T P Q K S L E E F Q D V
Cat Felis silvestris
Mouse Mus musculus Q61831 464 52514 T135 N V F T P Q K T L E E F Q D V
Rat Rattus norvegicus P49185 411 46789 S97 N V F T P Q K S L E E F Q D V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505581 424 48395 S97 N V F T P Q K S L E E F Q D V
Chicken Gallus gallus P79996 382 43990 L74 A K R A Y R E L V L L K C V N
Frog Xenopus laevis Q8QHK8 426 47910 S97 N V F T P Q K S L E E F Q D L
Zebra Danio Brachydanio rerio Q9DGD9 384 44121 K78 Y R E L V L M K C V N H K N I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P92208 372 43008 K66 F Q N V T H A K R A Y R E F K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q8WQG9 463 52867 S105 H V P E N Y Y S V T I G E A Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.9 99.7 99.5 N.A. 82.7 95 N.A. 82.4 74.7 91.5 77.5 N.A. 66.9 N.A. 57 N.A.
Protein Similarity: 100 55.7 100 100 N.A. 87.2 95.3 N.A. 89.6 81.5 95.3 84.5 N.A. 76.8 N.A. 68 N.A.
P-Site Identity: 100 13.3 100 100 N.A. 93.3 100 N.A. 100 0 93.3 0 N.A. 0 N.A. 13.3 N.A.
P-Site Similarity: 100 33.3 100 100 N.A. 100 100 N.A. 100 20 100 20 N.A. 6.6 N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 9 9 0 0 9 0 0 9 0 0 0 9 0 % A
% Cys: 0 0 0 0 0 0 0 0 9 0 0 0 9 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 59 0 % D
% Glu: 0 0 9 9 0 0 9 0 0 59 59 0 17 9 0 % E
% Phe: 9 0 59 0 0 0 0 0 0 0 9 59 0 9 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % G
% His: 9 0 0 0 0 9 0 0 0 0 0 9 0 0 0 % H
% Ile: 0 0 0 9 0 0 0 0 0 0 9 0 0 0 17 % I
% Lys: 9 9 0 0 9 9 59 17 0 0 0 9 9 0 9 % K
% Leu: 0 0 0 9 0 9 9 9 59 9 9 0 0 0 9 % L
% Met: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % M
% Asn: 59 0 9 0 9 0 0 0 0 0 9 0 0 9 9 % N
% Pro: 0 0 9 0 59 0 0 0 0 9 0 0 0 0 0 % P
% Gln: 0 9 0 0 0 59 0 0 0 0 0 9 59 0 9 % Q
% Arg: 0 9 9 0 0 9 0 0 17 0 0 9 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 67 0 0 0 0 9 0 0 % S
% Thr: 0 0 0 59 9 0 0 9 0 9 0 0 0 0 0 % T
% Val: 0 75 0 9 9 0 0 0 17 9 0 0 0 9 50 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 9 9 9 0 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _