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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPK8
All Species:
15.76
Human Site:
S400
Identified Species:
31.52
UniProt:
P45983
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45983
NP_002741.1
427
48296
S400
S
S
S
V
N
D
V
S
S
M
S
T
D
P
T
Chimpanzee
Pan troglodytes
Q9N272
365
41989
Y343
D
E
W
K
Q
H
I
Y
K
E
I
V
N
F
S
Rhesus Macaque
Macaca mulatta
XP_001108865
427
48293
S400
S
S
S
V
N
D
V
S
S
M
S
T
D
P
T
Dog
Lupus familis
XP_534943
427
48266
S400
S
S
S
V
N
D
V
S
S
M
S
T
D
P
T
Cat
Felis silvestris
Mouse
Mus musculus
Q61831
464
52514
S438
S
A
V
N
D
I
S
S
M
S
T
D
Q
T
L
Rat
Rattus norvegicus
P49185
411
46789
Q388
A
A
V
I
N
G
S
Q
H
P
V
S
S
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505581
424
48395
S400
I
N
D
I
S
S
M
S
T
E
Q
T
L
A
S
Chicken
Gallus gallus
P79996
382
43990
E359
W
K
E
L
I
Y
K
E
V
M
D
W
E
E
R
Frog
Xenopus laevis
Q8QHK8
426
47910
S400
S
S
S
G
D
A
S
S
M
S
T
D
P
T
L
Zebra Danio
Brachydanio rerio
Q9DGD9
384
44121
E362
L
I
Y
K
E
V
L
E
W
E
E
R
T
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P92208
372
43008
Q350
E
R
E
H
T
V
E
Q
W
K
E
L
I
Y
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q8WQG9
463
52867
M435
P
L
P
Y
D
H
N
M
D
V
E
Q
N
V
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.9
99.7
99.5
N.A.
82.7
95
N.A.
82.4
74.7
91.5
77.5
N.A.
66.9
N.A.
57
N.A.
Protein Similarity:
100
55.7
100
100
N.A.
87.2
95.3
N.A.
89.6
81.5
95.3
84.5
N.A.
76.8
N.A.
68
N.A.
P-Site Identity:
100
0
100
100
N.A.
13.3
13.3
N.A.
13.3
6.6
26.6
0
N.A.
0
N.A.
0
N.A.
P-Site Similarity:
100
20
100
100
N.A.
33.3
46.6
N.A.
53.3
20
40
6.6
N.A.
0
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
17
0
0
0
9
0
0
0
0
0
0
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
9
0
25
25
0
0
9
0
9
17
25
0
9
% D
% Glu:
9
9
17
0
9
0
9
17
0
25
25
0
9
9
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
0
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
9
0
17
0
0
9
0
0
0
0
0
0
% H
% Ile:
9
9
0
17
9
9
9
0
0
0
9
0
9
0
0
% I
% Lys:
0
9
0
17
0
0
9
0
9
9
0
0
0
9
0
% K
% Leu:
9
9
0
9
0
0
9
0
0
0
0
9
9
0
17
% L
% Met:
0
0
0
0
0
0
9
9
17
34
0
0
0
0
0
% M
% Asn:
0
9
0
9
34
0
9
0
0
0
0
0
17
0
9
% N
% Pro:
9
0
9
0
0
0
0
0
0
9
0
0
9
34
0
% P
% Gln:
0
0
0
0
9
0
0
17
0
0
9
9
9
0
0
% Q
% Arg:
0
9
0
0
0
0
0
0
0
0
0
9
0
0
9
% R
% Ser:
42
34
34
0
9
9
25
50
25
17
25
9
9
0
25
% S
% Thr:
0
0
0
0
9
0
0
0
9
0
17
34
9
17
25
% T
% Val:
0
0
17
25
0
17
25
0
9
9
9
9
0
9
0
% V
% Trp:
9
0
9
0
0
0
0
0
17
0
0
9
0
0
0
% W
% Tyr:
0
0
9
9
0
9
0
9
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _