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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAFAH1B1 All Species: 43.03
Human Site: S315 Identified Species: 67.62
UniProt: P43034 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P43034 NP_000421.1 410 46638 S315 G P F L L S G S R D K T I K M
Chimpanzee Pan troglodytes Q5IS43 410 46712 S315 G P F L L S G S R D K T I K M
Rhesus Macaque Macaca mulatta XP_001087675 410 46682 S315 G P F L L S G S R D K T I K M
Dog Lupus familis XP_868519 415 47277 S320 G P F L L S G S R D K T I K M
Cat Felis silvestris
Mouse Mus musculus Q9D7H2 328 36014 L234 T L D N T L K L W D Y S R G R
Rat Rattus norvegicus P63004 410 46652 S315 G P F L L S G S R D K T I K M
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q9PTR5 410 46646 S315 G P F L L S G S R D K T I K M
Frog Xenopus laevis Q6DE72 410 46731 S315 G P F L L S G S R D K T I K M
Zebra Danio Brachydanio rerio Q803D2 410 46511 S315 G P F L L S G S R D K T I K M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KNS3 411 46441 S316 G P F L A S G S R D K T I R I
Honey Bee Apis mellifera XP_392399 355 39633 R261 P F L A S G S R D K V I R V W
Nematode Worm Caenorhab. elegans Q9NDC9 404 45758 S309 T H I L F S G S R D R S I K A
Sea Urchin Strong. purpuratus XP_787226 407 46425 S312 T P F L V S G S R D K A I K I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39946 494 56882 L392 W E I P L P T L M A H R A P I
Red Bread Mold Neurospora crassa Q7RY30 453 49738 G326 S A E F M A T G S R D K S I R
Conservation
Percent
Protein Identity: 100 99.5 99.2 98.5 N.A. 26.3 99.7 N.A. N.A. 99 97.3 93.4 N.A. 70 63.9 57.3 75.6
Protein Similarity: 100 99.7 99.7 98.8 N.A. 45.6 100 N.A. N.A. 100 99.2 97.5 N.A. 87.3 74.3 76.8 89
P-Site Identity: 100 100 100 100 N.A. 6.6 100 N.A. N.A. 100 100 100 N.A. 80 0 53.3 73.3
P-Site Similarity: 100 100 100 100 N.A. 13.3 100 N.A. N.A. 100 100 100 N.A. 93.3 0 66.6 86.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.1 45.7
Protein Similarity: N.A. N.A. N.A. N.A. 45.9 63.5
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 0
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 7 7 7 0 0 0 7 0 7 7 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 0 0 0 0 0 7 80 7 0 0 0 0 % D
% Glu: 0 7 7 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 7 67 7 7 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 60 0 0 0 0 7 74 7 0 0 0 0 0 7 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 0 14 0 0 0 0 0 0 0 0 7 74 7 20 % I
% Lys: 0 0 0 0 0 0 7 0 0 7 67 7 0 67 0 % K
% Leu: 0 7 7 74 60 7 0 14 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 7 0 0 0 7 0 0 0 0 0 54 % M
% Asn: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 7 67 0 7 0 7 0 0 0 0 0 0 0 7 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 7 74 7 7 7 14 7 14 % R
% Ser: 7 0 0 0 7 74 7 74 7 0 0 14 7 0 0 % S
% Thr: 20 0 0 0 7 0 14 0 0 0 0 60 0 0 0 % T
% Val: 0 0 0 0 7 0 0 0 0 0 7 0 0 7 0 % V
% Trp: 7 0 0 0 0 0 0 0 7 0 0 0 0 0 7 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _