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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFR
All Species:
36.67
Human Site:
Y538
Identified Species:
57.62
UniProt:
P42898
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42898
NP_005948.3
656
74597
Y538
K
Y
E
L
R
V
N
Y
H
L
V
N
V
K
G
Chimpanzee
Pan troglodytes
XP_001141362
697
78964
Y579
K
Y
E
L
R
V
N
Y
H
L
V
N
V
K
G
Rhesus Macaque
Macaca mulatta
XP_001105188
697
79008
Y579
K
Y
E
L
R
V
N
Y
H
L
V
N
V
K
G
Dog
Lupus familis
XP_535405
780
87445
Y663
K
Y
E
L
R
V
N
Y
H
I
V
D
V
K
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9WU20
654
74631
Y537
T
Y
E
L
R
V
N
Y
H
I
V
D
V
K
G
Rat
Rattus norvegicus
XP_342976
695
78719
Y578
T
Y
E
L
R
V
N
Y
H
I
V
D
V
K
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516302
646
73079
Y535
K
Y
E
L
R
V
N
Y
H
I
V
N
V
K
G
Chicken
Gallus gallus
XP_417645
508
58330
K403
N
Y
H
I
V
N
V
K
G
Q
N
I
T
N
A
Frog
Xenopus laevis
NP_001080092
643
73624
Y532
R
Y
E
P
R
V
N
Y
H
I
V
N
V
H
G
Zebra Danio
Brachydanio rerio
NP_001121727
656
74637
Y538
K
Y
E
P
R
V
N
Y
Q
I
V
N
V
Q
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17693
663
75468
N554
R
E
F
P
V
R
V
N
Y
H
A
I
N
K
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002310366
608
67799
P504
V
E
R
C
K
A
F
P
L
V
T
Y
M
A
V
Maize
Zea mays
Q9SE94
593
66410
F489
L
I
E
K
I
K
A
F
P
S
L
T
Y
I
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SE60
592
66270
A488
T
L
V
E
K
S
K
A
F
P
S
I
T
Y
M
Baker's Yeast
Sacchar. cerevisiae
P53128
600
68542
Y496
K
N
N
E
F
L
T
Y
F
A
I
D
S
Q
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.9
91.9
76.4
N.A.
89.9
83.8
N.A.
85
64.9
79.2
77.2
N.A.
N.A.
N.A.
46.4
N.A.
Protein Similarity:
100
94.1
93.1
80.7
N.A.
95.1
89.7
N.A.
92.5
71.4
88.5
87.5
N.A.
N.A.
N.A.
67.7
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
80
80
N.A.
93.3
6.6
73.3
73.3
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
13.3
86.6
86.6
N.A.
N.A.
N.A.
20
N.A.
Percent
Protein Identity:
43.4
41.7
N.A.
41
38.7
N.A.
Protein Similarity:
60
59.1
N.A.
58.8
57.3
N.A.
P-Site Identity:
0
6.6
N.A.
0
20
N.A.
P-Site Similarity:
20
20
N.A.
6.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
7
7
0
7
7
0
0
7
14
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
27
0
0
7
% D
% Glu:
0
14
67
14
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
7
0
7
0
7
7
14
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
67
% G
% His:
0
0
7
0
0
0
0
0
54
7
0
0
0
7
0
% H
% Ile:
0
7
0
7
7
0
0
0
0
40
7
20
0
7
0
% I
% Lys:
47
0
0
7
14
7
7
7
0
0
0
0
0
54
0
% K
% Leu:
7
7
0
47
0
7
0
0
7
20
7
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% M
% Asn:
7
7
7
0
0
7
60
7
0
0
7
40
7
7
0
% N
% Pro:
0
0
0
20
0
0
0
7
7
7
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
7
7
0
0
0
14
0
% Q
% Arg:
14
0
7
0
60
7
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
7
0
0
0
7
7
0
7
0
0
% S
% Thr:
20
0
0
0
0
0
7
0
0
0
7
7
14
0
0
% T
% Val:
7
0
7
0
14
60
14
0
0
7
60
0
60
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
67
0
0
0
0
0
67
7
0
0
7
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _