KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFR
All Species:
16.97
Human Site:
T639
Identified Species:
26.67
UniProt:
P42898
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42898
NP_005948.3
656
74597
T639
L
W
Q
V
V
E
D
T
L
E
L
L
N
R
P
Chimpanzee
Pan troglodytes
XP_001141362
697
78964
T680
L
W
Q
V
V
E
D
T
L
E
L
V
N
R
P
Rhesus Macaque
Macaca mulatta
XP_001105188
697
79008
A680
L
W
Q
V
V
E
D
A
L
E
L
L
N
R
P
Dog
Lupus familis
XP_535405
780
87445
T764
L
W
Q
V
V
E
D
T
F
E
L
L
K
G
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9WU20
654
74631
T638
L
W
Q
V
V
E
D
T
F
E
L
L
N
R
H
Rat
Rattus norvegicus
XP_342976
695
78719
T679
L
W
Q
V
V
E
D
T
F
E
L
L
N
R
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516302
646
73079
L629
E
F
P
L
D
N
C
L
W
Q
V
V
E
D
T
Chicken
Gallus gallus
XP_417645
508
58330
L491
D
F
P
L
E
N
C
L
W
Q
V
V
D
D
T
Frog
Xenopus laevis
NP_001080092
643
73624
W627
F
P
L
E
N
C
L
W
Q
V
I
E
D
T
F
Zebra Danio
Brachydanio rerio
NP_001121727
656
74637
M639
L
W
Q
V
I
E
D
M
F
A
L
L
D
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17693
663
75468
P647
V
D
N
D
F
Q
K
P
S
V
L
F
D
V
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002310366
608
67799
V592
S
Y
F
L
V
S
L
V
D
N
D
Y
I
H
G
Maize
Zea mays
Q9SE94
593
66410
L577
K
T
Y
Y
L
V
S
L
V
D
N
D
Y
V
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SE60
592
66270
S576
K
N
S
Y
Y
L
V
S
L
V
D
N
N
Y
I
Baker's Yeast
Sacchar. cerevisiae
P53128
600
68542
N584
C
L
V
N
I
V
D
N
D
Y
I
S
P
D
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.9
91.9
76.4
N.A.
89.9
83.8
N.A.
85
64.9
79.2
77.2
N.A.
N.A.
N.A.
46.4
N.A.
Protein Similarity:
100
94.1
93.1
80.7
N.A.
95.1
89.7
N.A.
92.5
71.4
88.5
87.5
N.A.
N.A.
N.A.
67.7
N.A.
P-Site Identity:
100
93.3
93.3
80
N.A.
86.6
86.6
N.A.
0
0
0
53.3
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
93.3
80
N.A.
86.6
86.6
N.A.
33.3
40
13.3
66.6
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
43.4
41.7
N.A.
41
38.7
N.A.
Protein Similarity:
60
59.1
N.A.
58.8
57.3
N.A.
P-Site Identity:
6.6
0
N.A.
13.3
6.6
N.A.
P-Site Similarity:
20
20
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
7
0
7
0
0
0
0
0
% A
% Cys:
7
0
0
0
0
7
14
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
0
7
7
0
54
0
14
7
14
7
27
20
7
% D
% Glu:
7
0
0
7
7
47
0
0
0
40
0
7
7
0
0
% E
% Phe:
7
14
7
0
7
0
0
0
27
0
0
7
0
0
7
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
14
% H
% Ile:
0
0
0
0
14
0
0
0
0
0
14
0
7
0
7
% I
% Lys:
14
0
0
0
0
0
7
0
0
0
0
0
7
0
0
% K
% Leu:
47
7
7
20
7
7
14
20
27
0
54
40
0
0
7
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
7
7
7
7
14
0
7
0
7
7
7
40
0
0
% N
% Pro:
0
7
14
0
0
0
0
7
0
0
0
0
7
0
27
% P
% Gln:
0
0
47
0
0
7
0
0
7
14
0
0
0
0
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
34
0
% R
% Ser:
7
0
7
0
0
7
7
7
7
0
0
7
0
7
7
% S
% Thr:
0
7
0
0
0
0
0
34
0
0
0
0
0
7
14
% T
% Val:
7
0
7
47
47
14
7
7
7
20
14
20
0
14
0
% V
% Trp:
0
47
0
0
0
0
0
7
14
0
0
0
0
0
0
% W
% Tyr:
0
7
7
14
7
0
0
0
0
7
0
7
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _