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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFR
All Species:
40.3
Human Site:
S394
Identified Species:
63.33
UniProt:
P42898
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42898
NP_005948.3
656
74597
S394
G
R
W
G
N
S
S
S
P
A
F
G
E
L
K
Chimpanzee
Pan troglodytes
XP_001141362
697
78964
S435
G
R
W
G
N
S
S
S
P
A
F
G
E
L
K
Rhesus Macaque
Macaca mulatta
XP_001105188
697
79008
S435
G
R
W
G
N
S
S
S
P
A
F
G
E
L
K
Dog
Lupus familis
XP_535405
780
87445
S519
G
R
W
G
N
S
S
S
P
A
F
G
E
L
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9WU20
654
74631
S393
G
R
W
G
N
S
S
S
P
A
F
G
E
L
K
Rat
Rattus norvegicus
XP_342976
695
78719
S434
G
R
W
G
N
S
S
S
P
A
F
G
E
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516302
646
73079
S391
G
R
W
G
N
S
S
S
P
A
F
G
E
L
K
Chicken
Gallus gallus
XP_417645
508
58330
D260
P
A
F
G
E
L
K
D
Y
Y
L
F
Y
L
K
Frog
Xenopus laevis
NP_001080092
643
73624
S388
G
R
W
G
N
S
S
S
P
A
F
G
E
L
K
Zebra Danio
Brachydanio rerio
NP_001121727
656
74637
S394
G
R
W
G
N
S
S
S
P
A
F
G
E
L
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17693
663
75468
S408
G
R
W
G
N
S
S
S
P
A
F
G
D
V
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002310366
608
67799
D361
L
S
R
T
I
G
W
D
Q
Y
P
H
G
R
W
Maize
Zea mays
Q9SE94
593
66410
W346
Y
L
K
R
T
L
G
W
D
Q
Y
P
H
G
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SE60
592
66270
G345
S
Y
I
S
R
T
K
G
W
N
D
F
P
H
G
Baker's Yeast
Sacchar. cerevisiae
P53128
600
68542
F353
S
Q
W
A
V
D
E
F
P
N
G
R
F
G
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.9
91.9
76.4
N.A.
89.9
83.8
N.A.
85
64.9
79.2
77.2
N.A.
N.A.
N.A.
46.4
N.A.
Protein Similarity:
100
94.1
93.1
80.7
N.A.
95.1
89.7
N.A.
92.5
71.4
88.5
87.5
N.A.
N.A.
N.A.
67.7
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
20
100
93.3
N.A.
N.A.
N.A.
80
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
26.6
100
93.3
N.A.
N.A.
N.A.
93.3
N.A.
Percent
Protein Identity:
43.4
41.7
N.A.
41
38.7
N.A.
Protein Similarity:
60
59.1
N.A.
58.8
57.3
N.A.
P-Site Identity:
0
0
N.A.
0
13.3
N.A.
P-Site Similarity:
0
13.3
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
0
0
0
0
67
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
7
0
14
7
0
7
0
7
0
7
% D
% Glu:
0
0
0
0
7
0
7
0
0
0
0
0
60
0
0
% E
% Phe:
0
0
7
0
0
0
0
7
0
0
67
14
7
0
0
% F
% Gly:
67
0
0
74
0
7
7
7
0
0
7
67
7
14
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
7
7
0
% H
% Ile:
0
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
7
0
0
0
14
0
0
0
0
0
0
0
60
% K
% Leu:
7
7
0
0
0
14
0
0
0
0
7
0
0
67
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
67
0
0
0
0
14
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
74
0
7
7
7
0
0
% P
% Gln:
0
7
0
0
0
0
0
0
7
7
0
0
0
0
0
% Q
% Arg:
0
67
7
7
7
0
0
0
0
0
0
7
0
7
7
% R
% Ser:
14
7
0
7
0
67
67
67
0
0
0
0
0
0
7
% S
% Thr:
0
0
0
7
7
7
0
0
0
0
0
0
0
0
7
% T
% Val:
0
0
0
0
7
0
0
0
0
0
0
0
0
7
0
% V
% Trp:
0
0
74
0
0
0
7
7
7
0
0
0
0
0
7
% W
% Tyr:
7
7
0
0
0
0
0
0
7
14
7
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _