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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFR
All Species:
10.3
Human Site:
S18
Identified Species:
16.19
UniProt:
P42898
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42898
NP_005948.3
656
74597
S18
L
N
P
C
L
E
G
S
A
S
S
G
S
E
S
Chimpanzee
Pan troglodytes
XP_001141362
697
78964
S59
L
N
P
C
L
E
G
S
A
S
S
G
S
E
S
Rhesus Macaque
Macaca mulatta
XP_001105188
697
79008
S59
L
N
P
C
L
E
G
S
A
S
S
S
S
E
S
Dog
Lupus familis
XP_535405
780
87445
G60
G
P
T
P
R
S
E
G
S
S
S
G
S
E
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9WU20
654
74631
G17
S
P
N
P
R
S
E
G
S
S
S
G
S
E
S
Rat
Rattus norvegicus
XP_342976
695
78719
G58
S
P
S
P
R
S
E
G
S
S
S
G
S
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516302
646
73079
S18
R
R
S
S
S
S
S
S
G
S
E
G
S
K
D
Chicken
Gallus gallus
XP_417645
508
58330
Frog
Xenopus laevis
NP_001080092
643
73624
A17
G
T
A
S
C
S
S
A
E
N
S
K
E
S
S
Zebra Danio
Brachydanio rerio
NP_001121727
656
74637
G18
H
S
K
S
D
S
S
G
A
S
N
S
G
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17693
663
75468
M25
K
I
D
S
L
S
T
M
P
Y
C
G
V
E
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002310366
608
67799
N18
A
G
G
G
G
D
A
N
G
N
G
G
D
N
S
Maize
Zea mays
Q9SE94
593
66410
L8
M
K
V
I
E
K
I
L
E
A
A
G
D
G
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SE60
592
66270
Baker's Yeast
Sacchar. cerevisiae
P53128
600
68542
G15
E
Q
H
R
Q
T
S
G
K
P
T
Y
S
F
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.9
91.9
76.4
N.A.
89.9
83.8
N.A.
85
64.9
79.2
77.2
N.A.
N.A.
N.A.
46.4
N.A.
Protein Similarity:
100
94.1
93.1
80.7
N.A.
95.1
89.7
N.A.
92.5
71.4
88.5
87.5
N.A.
N.A.
N.A.
67.7
N.A.
P-Site Identity:
100
100
93.3
40
N.A.
40
40
N.A.
26.6
0
13.3
26.6
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
100
100
93.3
46.6
N.A.
46.6
46.6
N.A.
33.3
0
26.6
40
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
43.4
41.7
N.A.
41
38.7
N.A.
Protein Similarity:
60
59.1
N.A.
58.8
57.3
N.A.
P-Site Identity:
13.3
6.6
N.A.
0
6.6
N.A.
P-Site Similarity:
33.3
33.3
N.A.
0
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
0
0
0
7
7
27
7
7
0
0
0
0
% A
% Cys:
0
0
0
20
7
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
0
7
0
7
7
0
0
0
0
0
0
14
0
7
% D
% Glu:
7
0
0
0
7
20
20
0
14
0
7
0
7
54
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
14
7
7
7
7
0
20
34
14
0
7
60
7
7
0
% G
% His:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
7
0
0
7
0
0
0
0
0
0
0
0
% I
% Lys:
7
7
7
0
0
7
0
0
7
0
0
7
0
7
0
% K
% Leu:
20
0
0
0
27
0
0
7
0
0
0
0
0
0
0
% L
% Met:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
20
7
0
0
0
0
7
0
14
7
0
0
7
0
% N
% Pro:
0
20
20
20
0
0
0
0
7
7
0
0
0
0
0
% P
% Gln:
0
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
7
0
7
20
0
0
0
0
0
0
0
0
0
7
% R
% Ser:
14
7
14
27
7
47
27
27
20
54
47
14
54
7
60
% S
% Thr:
0
7
7
0
0
7
7
0
0
0
7
0
0
0
7
% T
% Val:
0
0
7
0
0
0
0
0
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
7
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _