Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EPS15 All Species: 12.73
Human Site: S14 Identified Species: 28
UniProt: P42566 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42566 NP_001153441.1 896 98656 S14 L S L T Q L S S G N P V Y E K
Chimpanzee Pan troglodytes XP_001139393 896 98643 S14 L S L T Q L S S G N S V Y E K
Rhesus Macaque Macaca mulatta XP_001113811 1015 110551 T119 G A A V A I P T G N S L Y E S
Dog Lupus familis XP_532580 889 97932 T15 F K S F Q V D T G N T G R V L
Cat Felis silvestris
Mouse Mus musculus P42567 897 98453 S14 L S L T Q L S S G N P V Y E K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026454 920 100691 P15 T Q L S S A N P V Y E K F Y R
Frog Xenopus laevis O42287 1270 143652 V19 L D I W A I T V E E R A K H D
Zebra Danio Brachydanio rerio XP_002663145 1039 114340 P15 T Q L S S G N P V Y E K Y Y R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001122937 1043 116535 H14 P T Q V A G S H T A I Y E A Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001192039 1179 125310 E14 A P W V V T S E D S A N C Y I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P34216 1381 150765 E14 R T P L S S Q E Q A F Y N Q K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 43.2 91.5 N.A. 89.3 N.A. N.A. N.A. 74.6 21 50.5 N.A. N.A. 30.1 N.A. 29.6
Protein Similarity: 100 99.7 59.5 94.5 N.A. 93.4 N.A. N.A. N.A. 84.1 34.9 64.4 N.A. N.A. 48.2 N.A. 44.3
P-Site Identity: 100 93.3 26.6 20 N.A. 100 N.A. N.A. N.A. 6.6 6.6 13.3 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 100 93.3 53.3 33.3 N.A. 100 N.A. N.A. N.A. 33.3 26.6 33.3 N.A. N.A. 13.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 35.5 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 10 0 28 10 0 0 0 19 10 10 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % C
% Asp: 0 10 0 0 0 0 10 0 10 0 0 0 0 0 10 % D
% Glu: 0 0 0 0 0 0 0 19 10 10 19 0 10 37 0 % E
% Phe: 10 0 0 10 0 0 0 0 0 0 10 0 10 0 0 % F
% Gly: 10 0 0 0 0 19 0 0 46 0 0 10 0 0 0 % G
% His: 0 0 0 0 0 0 0 10 0 0 0 0 0 10 0 % H
% Ile: 0 0 10 0 0 19 0 0 0 0 10 0 0 0 10 % I
% Lys: 0 10 0 0 0 0 0 0 0 0 0 19 10 0 37 % K
% Leu: 37 0 46 10 0 28 0 0 0 0 0 10 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 19 0 0 46 0 10 10 0 0 % N
% Pro: 10 10 10 0 0 0 10 19 0 0 19 0 0 0 0 % P
% Gln: 0 19 10 0 37 0 10 0 10 0 0 0 0 10 0 % Q
% Arg: 10 0 0 0 0 0 0 0 0 0 10 0 10 0 19 % R
% Ser: 0 28 10 19 28 10 46 28 0 10 19 0 0 0 10 % S
% Thr: 19 19 0 28 0 10 10 19 10 0 10 0 0 0 0 % T
% Val: 0 0 0 28 10 10 0 10 19 0 0 28 0 10 0 % V
% Trp: 0 0 10 10 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 19 0 19 46 28 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _