KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CB
All Species:
33.33
Human Site:
Y990
Identified Species:
52.38
UniProt:
P42338
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42338
NP_006210.1
1070
122762
Y990
R
Q
C
C
E
D
A
Y
L
I
L
R
R
H
G
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
Y964
R
G
Y
C
E
R
A
Y
T
I
L
R
R
H
G
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
Y990
R
Q
C
C
E
D
A
Y
L
I
L
R
R
H
G
Dog
Lupus familis
XP_534280
1070
122787
Y990
R
Q
C
C
E
D
A
Y
L
I
L
R
R
H
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTI9
1064
121735
Y984
R
Q
C
C
E
D
A
Y
L
I
L
R
R
H
G
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
Y990
R
Q
C
C
E
D
A
Y
L
I
L
R
R
H
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
R1087
K
F
G
I
K
R
E
R
V
P
F
I
L
T
Y
Chicken
Gallus gallus
NP_001026482
1066
122000
Y986
R
Q
Y
C
E
E
A
Y
L
I
L
R
K
H
G
Frog
Xenopus laevis
Q6AZN6
886
101139
Y811
A
F
L
H
L
R
R
Y
S
N
L
I
L
N
L
Zebra Danio
Brachydanio rerio
XP_001923257
1022
117051
Y944
R
Q
Y
C
E
E
A
Y
M
I
L
R
K
N
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
F990
Q
S
H
C
E
Q
A
F
L
V
L
R
Q
H
G
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
Y1104
K
T
L
C
V
E
A
Y
E
V
M
W
N
N
R
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
A971
F
R
R
C
C
E
E
A
F
M
I
L
R
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
K739
E
A
Y
N
I
L
R
K
S
S
N
L
I
L
N
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
N800
A
Y
S
I
L
R
R
N
A
G
L
I
L
N
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
56.5
99.6
97.2
N.A.
95.2
95.8
N.A.
81.1
86.6
23.6
65.5
N.A.
N.A.
46.6
26.4
42.9
Protein Similarity:
100
72.9
99.9
98.8
N.A.
97
97.8
N.A.
85.3
93.6
41.3
79.7
N.A.
N.A.
65.6
47.8
63.6
P-Site Identity:
100
73.3
100
100
N.A.
100
100
N.A.
0
80
13.3
66.6
N.A.
N.A.
53.3
20
13.3
P-Site Similarity:
100
73.3
100
100
N.A.
100
100
N.A.
20
93.3
20
93.3
N.A.
N.A.
80
53.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
23.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
41.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
0
0
0
0
67
7
7
0
0
0
0
0
0
% A
% Cys:
0
0
34
74
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
34
0
0
0
0
0
0
0
0
0
% D
% Glu:
7
0
0
0
60
27
14
0
7
0
0
0
0
0
0
% E
% Phe:
7
14
0
0
0
0
0
7
7
0
7
0
0
0
0
% F
% Gly:
0
7
7
0
0
0
0
0
0
7
0
0
0
0
60
% G
% His:
0
0
7
7
0
0
0
0
0
0
0
0
0
54
0
% H
% Ile:
0
0
0
14
7
0
0
0
0
54
7
20
7
0
0
% I
% Lys:
14
0
0
0
7
0
0
7
0
0
0
0
14
0
0
% K
% Leu:
0
0
14
0
14
7
0
0
47
0
74
14
20
7
14
% L
% Met:
0
0
0
0
0
0
0
0
7
7
7
0
0
0
0
% M
% Asn:
0
0
0
7
0
0
0
7
0
7
7
0
7
27
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% P
% Gln:
7
47
0
0
0
7
0
0
0
0
0
0
7
0
0
% Q
% Arg:
54
7
7
0
0
27
20
7
0
0
0
60
47
7
14
% R
% Ser:
0
7
7
0
0
0
0
0
14
7
0
0
0
0
0
% S
% Thr:
0
7
0
0
0
0
0
0
7
0
0
0
0
7
0
% T
% Val:
0
0
0
0
7
0
0
0
7
14
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
7
27
0
0
0
0
67
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _