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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CB
All Species:
27.58
Human Site:
Y193
Identified Species:
43.33
UniProt:
P42338
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42338
NP_006210.1
1070
122762
Y193
E
N
L
E
D
K
L
Y
G
G
K
L
I
V
A
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
N187
P
G
T
L
R
L
P
N
R
A
L
L
V
N
V
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
Y193
E
N
L
E
D
K
L
Y
G
G
K
L
I
V
A
Dog
Lupus familis
XP_534280
1070
122787
Y193
E
N
L
E
D
K
L
Y
G
G
K
L
I
V
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTI9
1064
121735
Y187
E
N
L
E
D
K
L
Y
G
G
K
L
V
V
A
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
Y193
E
N
L
E
D
K
L
Y
G
G
K
L
V
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
Y325
E
N
I
E
D
K
L
Y
G
G
H
L
V
V
A
Chicken
Gallus gallus
NP_001026482
1066
122000
Y187
E
N
F
Q
D
K
L
Y
S
G
N
L
V
V
A
Frog
Xenopus laevis
Q6AZN6
886
101139
A107
L
P
R
S
A
Q
V
A
L
T
I
W
D
V
Y
Zebra Danio
Brachydanio rerio
XP_001923257
1022
117051
I186
T
H
G
P
E
E
D
I
G
A
R
S
N
Y
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
K187
K
N
I
E
C
R
L
K
D
G
N
I
V
L
V
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
K254
K
D
L
E
S
K
V
K
A
A
K
L
S
Y
Q
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
T196
R
F
S
S
S
L
S
T
T
S
V
L
Q
V
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
S35
N
L
P
V
K
K
S
S
D
S
G
V
V
S
I
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
I96
D
Y
W
L
T
L
P
I
R
I
K
Q
L
T
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
56.5
99.6
97.2
N.A.
95.2
95.8
N.A.
81.1
86.6
23.6
65.5
N.A.
N.A.
46.6
26.4
42.9
Protein Similarity:
100
72.9
99.9
98.8
N.A.
97
97.8
N.A.
85.3
93.6
41.3
79.7
N.A.
N.A.
65.6
47.8
63.6
P-Site Identity:
100
6.6
100
100
N.A.
93.3
93.3
N.A.
80
66.6
6.6
6.6
N.A.
N.A.
26.6
33.3
13.3
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
93.3
80
20
33.3
N.A.
N.A.
66.6
53.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
23.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
41.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
0
7
7
20
0
0
0
0
47
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
0
0
47
0
7
0
14
0
0
0
7
0
0
% D
% Glu:
47
0
0
54
7
7
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
7
7
0
0
0
0
0
0
0
0
0
0
0
7
% F
% Gly:
0
7
7
0
0
0
0
0
47
54
7
0
0
0
0
% G
% His:
0
7
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
14
0
0
0
0
14
0
7
7
7
20
0
7
% I
% Lys:
14
0
0
0
7
60
0
14
0
0
47
0
0
0
7
% K
% Leu:
7
7
40
14
0
20
54
0
7
0
7
67
7
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
54
0
0
0
0
0
7
0
0
14
0
7
7
0
% N
% Pro:
7
7
7
7
0
0
14
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
7
0
7
0
0
0
0
0
7
7
0
7
% Q
% Arg:
7
0
7
0
7
7
0
0
14
0
7
0
0
0
0
% R
% Ser:
0
0
7
14
14
0
14
7
7
14
0
7
7
7
0
% S
% Thr:
7
0
7
0
7
0
0
7
7
7
0
0
0
7
0
% T
% Val:
0
0
0
7
0
0
14
0
0
0
7
7
47
60
20
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
47
0
0
0
0
0
14
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _