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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CB
All Species:
25.45
Human Site:
T721
Identified Species:
40
UniProt:
P42338
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42338
NP_006210.1
1070
122762
T721
E
A
L
N
K
L
K
T
L
N
S
L
I
K
L
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
A694
E
A
L
S
K
L
K
A
L
N
D
F
V
K
L
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
T721
E
A
L
N
K
L
K
T
L
N
S
L
I
K
L
Dog
Lupus familis
XP_534280
1070
122787
T721
E
A
L
N
K
L
K
T
L
N
S
L
I
K
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTI9
1064
121735
T715
E
A
L
N
K
L
K
T
L
N
S
L
I
K
L
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
T721
E
A
L
N
K
L
K
T
L
N
S
L
I
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
C831
G
V
I
L
E
A
Y
C
R
G
S
V
G
H
M
Chicken
Gallus gallus
NP_001026482
1066
122000
T717
E
A
L
N
K
M
K
T
L
N
S
L
I
K
L
Frog
Xenopus laevis
Q6AZN6
886
101139
N564
A
V
Q
R
E
S
G
N
R
K
K
K
N
E
R
Zebra Danio
Brachydanio rerio
XP_001923257
1022
117051
A673
E
A
L
N
K
L
K
A
V
N
E
L
I
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
S721
E
C
L
G
K
L
K
S
A
S
E
Q
I
K
Q
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
R808
D
M
V
D
E
L
T
R
I
S
T
L
V
K
G
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
N699
E
S
L
N
K
M
K
N
L
N
E
L
I
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
N492
E
V
R
N
V
R
G
N
T
Q
K
K
I
E
K
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
D553
E
T
I
K
R
L
K
D
T
T
A
K
K
M
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
56.5
99.6
97.2
N.A.
95.2
95.8
N.A.
81.1
86.6
23.6
65.5
N.A.
N.A.
46.6
26.4
42.9
Protein Similarity:
100
72.9
99.9
98.8
N.A.
97
97.8
N.A.
85.3
93.6
41.3
79.7
N.A.
N.A.
65.6
47.8
63.6
P-Site Identity:
100
66.6
100
100
N.A.
100
100
N.A.
6.6
93.3
0
80
N.A.
N.A.
46.6
20
66.6
P-Site Similarity:
100
80
100
100
N.A.
100
100
N.A.
33.3
100
13.3
86.6
N.A.
N.A.
60
73.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
23.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
41.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
54
0
0
0
7
0
14
7
0
7
0
0
0
0
% A
% Cys:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
7
0
0
0
7
0
0
7
0
0
0
0
% D
% Glu:
80
0
0
0
20
0
0
0
0
0
20
0
0
14
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% F
% Gly:
7
0
0
7
0
0
14
0
0
7
0
0
7
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
14
0
0
0
0
0
7
0
0
0
67
0
0
% I
% Lys:
0
0
0
7
67
0
74
0
0
7
14
20
7
74
7
% K
% Leu:
0
0
67
7
0
67
0
0
54
0
0
60
0
0
54
% L
% Met:
0
7
0
0
0
14
0
0
0
0
0
0
0
7
7
% M
% Asn:
0
0
0
60
0
0
0
20
0
60
0
0
7
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
7
0
0
0
0
0
0
7
0
7
0
0
7
% Q
% Arg:
0
0
7
7
7
7
0
7
14
0
0
0
0
0
7
% R
% Ser:
0
7
0
7
0
7
0
7
0
14
47
0
0
0
7
% S
% Thr:
0
7
0
0
0
0
7
40
14
7
7
0
0
0
0
% T
% Val:
0
20
7
0
7
0
0
0
7
0
0
7
14
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _