KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CB
All Species:
37.27
Human Site:
S631
Identified Species:
58.57
UniProt:
P42338
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42338
NP_006210.1
1070
122762
S631
V
G
C
L
R
Q
M
S
D
E
E
L
S
Q
Y
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
T604
I
K
S
L
R
K
L
T
D
D
E
L
F
Q
Y
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
S631
V
G
C
L
R
Q
M
S
D
E
E
L
S
Q
Y
Dog
Lupus familis
XP_534280
1070
122787
S631
V
G
C
L
R
Q
M
S
D
E
E
L
S
Q
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTI9
1064
121735
S625
V
G
C
L
R
Q
M
S
D
E
E
L
S
Q
Y
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
S631
V
G
C
L
R
Q
M
S
D
E
E
L
S
Q
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
P747
E
L
L
D
F
N
Y
P
D
Q
Y
V
R
E
Y
Chicken
Gallus gallus
NP_001026482
1066
122000
S627
V
G
C
L
K
Q
M
S
D
E
E
L
S
Q
Y
Frog
Xenopus laevis
Q6AZN6
886
101139
A482
C
T
F
L
I
S
R
A
C
K
N
S
T
L
A
Zebra Danio
Brachydanio rerio
XP_001923257
1022
117051
S583
V
S
C
L
K
D
M
S
D
D
E
L
L
Q
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
S631
V
R
C
L
M
D
V
S
D
E
D
L
S
L
Y
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
S711
E
K
L
N
E
Q
L
S
P
V
T
F
H
L
F
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
T609
V
A
Q
G
L
S
S
T
D
D
Q
L
S
Q
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
Q410
C
L
S
Q
F
L
V
Q
R
A
L
Q
N
I
E
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
E471
E
S
E
T
S
G
T
E
S
L
P
I
V
I
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
56.5
99.6
97.2
N.A.
95.2
95.8
N.A.
81.1
86.6
23.6
65.5
N.A.
N.A.
46.6
26.4
42.9
Protein Similarity:
100
72.9
99.9
98.8
N.A.
97
97.8
N.A.
85.3
93.6
41.3
79.7
N.A.
N.A.
65.6
47.8
63.6
P-Site Identity:
100
46.6
100
100
N.A.
100
100
N.A.
13.3
93.3
6.6
66.6
N.A.
N.A.
60
13.3
40
P-Site Similarity:
100
80
100
100
N.A.
100
100
N.A.
33.3
100
26.6
80
N.A.
N.A.
73.3
26.6
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
23.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
41.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
7
0
7
0
0
0
0
7
% A
% Cys:
14
0
54
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
14
0
0
74
20
7
0
0
0
0
% D
% Glu:
20
0
7
0
7
0
0
7
0
47
54
0
0
7
7
% E
% Phe:
0
0
7
0
14
0
0
0
0
0
0
7
7
0
7
% F
% Gly:
0
40
0
7
0
7
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
7
0
0
0
7
0
0
0
0
0
0
7
0
14
0
% I
% Lys:
0
14
0
0
14
7
0
0
0
7
0
0
0
0
0
% K
% Leu:
0
14
14
67
7
7
14
0
0
7
7
67
7
20
0
% L
% Met:
0
0
0
0
7
0
47
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
7
0
0
0
0
7
0
7
0
0
% N
% Pro:
0
0
0
0
0
0
0
7
7
0
7
0
0
0
0
% P
% Gln:
0
0
7
7
0
47
0
7
0
7
7
7
0
60
0
% Q
% Arg:
0
7
0
0
40
0
7
0
7
0
0
0
7
0
0
% R
% Ser:
0
14
14
0
7
14
7
60
7
0
0
7
54
0
7
% S
% Thr:
0
7
0
7
0
0
7
14
0
0
7
0
7
0
0
% T
% Val:
60
0
0
0
0
0
14
0
0
7
0
7
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
0
0
0
7
0
0
0
74
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _