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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CB
All Species:
30.91
Human Site:
S463
Identified Species:
48.57
UniProt:
P42338
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42338
NP_006210.1
1070
122762
S463
D
I
I
L
H
S
W
S
S
F
P
D
E
L
E
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
P443
E
R
C
L
Y
M
W
P
S
V
P
D
E
K
G
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
S463
D
I
I
L
H
S
W
S
S
F
P
D
E
L
E
Dog
Lupus familis
XP_534280
1070
122787
S463
D
I
I
L
H
S
W
S
S
F
P
D
E
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTI9
1064
121735
S457
D
V
I
L
H
S
W
S
S
F
P
D
E
L
E
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
S463
D
V
I
L
H
S
W
S
S
F
P
D
E
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
S595
D
I
I
L
H
S
W
S
S
F
P
D
E
L
E
Chicken
Gallus gallus
NP_001026482
1066
122000
S458
E
F
V
L
H
S
W
S
S
F
P
D
E
L
E
Frog
Xenopus laevis
Q6AZN6
886
101139
W339
K
F
L
K
C
V
N
W
D
L
P
Q
E
A
K
Zebra Danio
Brachydanio rerio
XP_001923257
1022
117051
D419
H
C
W
S
S
F
P
D
E
L
E
E
M
L
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
Y455
M
T
L
Y
T
W
T
Y
A
E
D
M
Q
N
D
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
T544
H
L
W
A
P
E
P
T
A
N
R
S
R
I
G
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
L461
V
P
I
A
W
V
N
L
T
F
F
D
Y
R
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
S267
K
Q
L
K
L
A
R
S
L
D
R
G
I
I
D
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
W328
A
H
E
K
G
S
I
W
K
Y
R
Y
Y
L
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
56.5
99.6
97.2
N.A.
95.2
95.8
N.A.
81.1
86.6
23.6
65.5
N.A.
N.A.
46.6
26.4
42.9
Protein Similarity:
100
72.9
99.9
98.8
N.A.
97
97.8
N.A.
85.3
93.6
41.3
79.7
N.A.
N.A.
65.6
47.8
63.6
P-Site Identity:
100
40
100
100
N.A.
93.3
93.3
N.A.
100
80
13.3
6.6
N.A.
N.A.
0
0
20
P-Site Similarity:
100
53.3
100
100
N.A.
100
100
N.A.
100
93.3
26.6
13.3
N.A.
N.A.
26.6
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
23.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
41.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
14
0
7
0
0
14
0
0
0
0
7
0
% A
% Cys:
0
7
7
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
40
0
0
0
0
0
0
7
7
7
7
60
0
0
14
% D
% Glu:
14
0
7
0
0
7
0
0
7
7
7
7
60
0
47
% E
% Phe:
0
14
0
0
0
7
0
0
0
54
7
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
0
0
0
0
0
7
0
0
14
% G
% His:
14
7
0
0
47
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
27
47
0
0
0
7
0
0
0
0
0
7
14
0
% I
% Lys:
14
0
0
20
0
0
0
0
7
0
0
0
0
7
7
% K
% Leu:
0
7
20
54
7
0
0
7
7
14
0
0
0
60
0
% L
% Met:
7
0
0
0
0
7
0
0
0
0
0
7
7
0
7
% M
% Asn:
0
0
0
0
0
0
14
0
0
7
0
0
0
7
7
% N
% Pro:
0
7
0
0
7
0
14
7
0
0
60
0
0
0
0
% P
% Gln:
0
7
0
0
0
0
0
0
0
0
0
7
7
0
0
% Q
% Arg:
0
7
0
0
0
0
7
0
0
0
20
0
7
7
0
% R
% Ser:
0
0
0
7
7
54
0
54
54
0
0
7
0
0
7
% S
% Thr:
0
7
0
0
7
0
7
7
7
0
0
0
0
0
0
% T
% Val:
7
14
7
0
0
14
0
0
0
7
0
0
0
0
0
% V
% Trp:
0
0
14
0
7
7
54
14
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
7
0
0
7
0
7
0
7
14
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _