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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CB
All Species:
25.45
Human Site:
S183
Identified Species:
40
UniProt:
P42338
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42338
NP_006210.1
1070
122762
S183
Y
P
P
E
H
E
P
S
I
P
E
N
L
E
D
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
T177
Q
L
E
P
S
A
R
T
W
G
P
G
T
L
R
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
S183
Y
P
P
E
H
E
P
S
I
P
E
N
L
E
D
Dog
Lupus familis
XP_534280
1070
122787
S183
Y
P
P
E
H
E
P
S
I
L
E
N
L
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTI9
1064
121735
S177
Y
P
P
E
H
E
P
S
V
L
E
N
L
E
D
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
S183
Y
P
P
E
H
E
P
S
V
L
E
N
L
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
S315
Y
P
P
E
Q
E
A
S
I
L
E
N
I
E
D
Chicken
Gallus gallus
NP_001026482
1066
122000
V177
Y
P
P
E
Q
E
P
V
V
P
E
N
F
Q
D
Frog
Xenopus laevis
Q6AZN6
886
101139
Y97
W
L
K
L
P
V
K
Y
A
D
L
P
R
S
A
Zebra Danio
Brachydanio rerio
XP_001923257
1022
117051
W176
M
D
H
A
L
K
K
W
Q
T
T
H
G
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
T177
T
R
L
A
P
T
A
T
I
P
K
N
I
E
C
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
S244
Q
Y
L
C
V
G
E
S
C
P
K
D
L
E
S
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
I186
N
L
P
E
N
L
L
I
N
M
R
F
S
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
L25
V
T
F
R
I
E
K
L
D
G
N
L
P
V
K
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
R86
Y
I
P
F
R
N
S
R
T
W
D
Y
W
L
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
56.5
99.6
97.2
N.A.
95.2
95.8
N.A.
81.1
86.6
23.6
65.5
N.A.
N.A.
46.6
26.4
42.9
Protein Similarity:
100
72.9
99.9
98.8
N.A.
97
97.8
N.A.
85.3
93.6
41.3
79.7
N.A.
N.A.
65.6
47.8
63.6
P-Site Identity:
100
0
100
93.3
N.A.
86.6
86.6
N.A.
73.3
66.6
0
0
N.A.
N.A.
26.6
26.6
13.3
P-Site Similarity:
100
6.6
100
93.3
N.A.
93.3
93.3
N.A.
80
80
6.6
20
N.A.
N.A.
46.6
40
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
23.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
41.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
14
0
7
14
0
7
0
0
0
0
0
7
% A
% Cys:
0
0
0
7
0
0
0
0
7
0
0
0
0
0
7
% C
% Asp:
0
7
0
0
0
0
0
0
7
7
7
7
0
0
47
% D
% Glu:
0
0
7
54
0
54
7
0
0
0
47
0
0
54
7
% E
% Phe:
0
0
7
7
0
0
0
0
0
0
0
7
7
0
0
% F
% Gly:
0
0
0
0
0
7
0
0
0
14
0
7
7
0
0
% G
% His:
0
0
7
0
34
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
7
0
0
7
0
0
7
34
0
0
0
14
0
0
% I
% Lys:
0
0
7
0
0
7
20
0
0
0
14
0
0
0
7
% K
% Leu:
0
20
14
7
7
7
7
7
0
27
7
7
40
14
0
% L
% Met:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
7
0
0
0
7
7
0
0
7
0
7
54
0
0
0
% N
% Pro:
0
47
60
7
14
0
40
0
0
34
7
7
7
7
0
% P
% Gln:
14
0
0
0
14
0
0
0
7
0
0
0
0
7
0
% Q
% Arg:
0
7
0
7
7
0
7
7
0
0
7
0
7
0
7
% R
% Ser:
0
0
0
0
7
0
7
47
0
0
0
0
7
14
14
% S
% Thr:
7
7
0
0
0
7
0
14
7
7
7
0
7
0
7
% T
% Val:
7
0
0
0
7
7
0
7
20
0
0
0
0
7
0
% V
% Trp:
7
0
0
0
0
0
0
7
7
7
0
0
7
0
0
% W
% Tyr:
54
7
0
0
0
0
0
7
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _