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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
43.64
Human Site:
Y631
Identified Species:
68.57
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
Y631
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
Y611
T
D
D
E
L
F
Q
Y
L
L
Q
L
V
Q
V
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
Y638
S
D
E
E
L
S
Q
Y
L
L
Q
L
V
Q
V
Dog
Lupus familis
XP_546764
1044
119674
Y611
T
D
D
E
L
F
Q
Y
L
L
Q
L
V
Q
V
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
Y631
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
Y638
S
D
E
E
L
S
Q
Y
L
L
Q
L
V
Q
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
Y631
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
Chicken
Gallus gallus
NP_001004410
1068
124270
Y631
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
Frog
Xenopus laevis
Q6AZN6
886
101139
D502
Y
V
I
V
E
C
E
D
Q
D
T
Q
L
R
D
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
Y631
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
Y638
S
D
E
D
L
S
L
Y
L
L
Q
L
V
Q
A
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
F718
S
P
V
T
F
H
L
F
I
L
P
L
I
Q
A
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
Y616
T
D
D
Q
L
S
Q
Y
L
L
Q
L
V
Q
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
L430
R
W
Y
V
A
V
E
L
H
D
H
V
Y
A
K
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
N491
L
I
R
R
A
L
V
N
P
R
L
G
S
F
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
80
73.3
80
N.A.
100
73.3
N.A.
100
100
0
100
N.A.
N.A.
60
13.3
80
P-Site Similarity:
100
93.3
100
93.3
N.A.
100
100
N.A.
100
100
20
100
N.A.
N.A.
80
46.6
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
14
0
0
0
0
0
0
0
0
7
20
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
74
54
7
0
0
0
7
0
14
0
0
0
0
7
% D
% Glu:
0
0
20
27
7
0
14
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
7
14
0
7
0
0
0
0
0
7
7
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
7
0
0
7
0
7
0
0
0
0
% H
% Ile:
0
7
7
0
0
0
0
0
7
34
0
0
7
0
0
% I
% Lys:
0
0
0
34
0
0
0
0
0
0
0
0
0
0
7
% K
% Leu:
7
0
0
0
74
7
14
7
74
47
7
80
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
0
7
0
0
0
0
0
0
7
0
7
0
0
0
0
% P
% Gln:
0
0
0
7
0
0
67
0
7
0
74
7
0
80
0
% Q
% Arg:
7
0
7
7
0
0
0
0
0
7
0
0
0
7
0
% R
% Ser:
27
0
0
0
0
60
0
0
0
0
0
0
7
0
0
% S
% Thr:
54
0
0
7
0
0
0
0
0
0
7
0
0
0
0
% T
% Val:
0
7
7
14
0
7
7
0
0
0
0
7
74
0
60
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
7
0
0
0
0
74
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _