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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
26.36
Human Site:
Y606
Identified Species:
41.43
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
Y606
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
F587
L
E
L
L
D
F
S
F
P
D
C
H
V
G
S
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
Y614
L
E
L
L
D
F
N
Y
P
D
Q
Y
V
R
E
Dog
Lupus familis
XP_546764
1044
119674
F587
L
E
L
L
D
F
S
F
P
D
R
H
V
G
S
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
Y606
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
S
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
Y614
L
E
L
L
D
F
N
Y
P
D
Q
Y
V
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
Y606
M
E
L
L
D
C
N
Y
P
D
P
R
V
R
A
Chicken
Gallus gallus
NP_001004410
1068
124270
Y606
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
A
Frog
Xenopus laevis
Q6AZN6
886
101139
L478
E
Q
D
L
C
T
F
L
I
S
R
A
C
K
N
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
Y606
M
E
L
L
D
C
N
Y
P
D
P
M
I
R
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
Y614
L
E
L
L
D
Y
A
Y
A
D
Q
N
V
R
S
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
C693
L
T
L
L
G
K
R
C
T
D
R
V
I
R
K
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
L587
R
D
Q
L
P
H
A
L
P
R
L
L
K
C
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
Q406
S
D
R
S
C
L
S
Q
F
L
V
Q
R
A
L
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
T467
S
I
S
S
E
S
E
T
S
G
T
E
S
L
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
46.6
66.6
46.6
N.A.
93.3
66.6
N.A.
86.6
93.3
6.6
86.6
N.A.
N.A.
53.3
26.6
13.3
P-Site Similarity:
100
66.6
73.3
66.6
N.A.
93.3
73.3
N.A.
86.6
93.3
20
93.3
N.A.
N.A.
60
46.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
14
0
7
0
0
7
0
7
14
% A
% Cys:
0
0
0
0
14
34
0
7
0
0
7
0
7
7
0
% C
% Asp:
0
14
7
0
67
0
0
0
0
74
0
0
0
0
7
% D
% Glu:
7
67
0
0
7
0
7
0
0
0
0
7
0
0
14
% E
% Phe:
0
0
0
0
0
27
7
14
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
0
0
0
7
0
0
0
14
7
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
14
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
0
7
0
0
0
14
0
0
% I
% Lys:
0
0
0
0
0
7
0
0
0
0
0
0
7
7
7
% K
% Leu:
40
0
74
87
0
7
0
14
0
7
7
7
0
7
7
% L
% Met:
34
0
0
0
0
0
0
0
0
0
0
27
0
0
0
% M
% Asn:
0
0
0
0
0
0
47
0
0
0
0
7
0
0
7
% N
% Pro:
0
0
0
0
7
0
0
0
67
0
34
0
0
0
7
% P
% Gln:
0
7
7
0
0
0
0
7
0
0
20
7
0
0
0
% Q
% Arg:
7
0
7
0
0
0
7
0
0
7
20
7
7
60
0
% R
% Ser:
14
0
7
14
0
7
20
0
7
7
0
0
7
0
27
% S
% Thr:
0
7
0
0
0
7
0
7
7
0
7
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
7
7
60
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
54
0
0
0
14
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _