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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
18.48
Human Site:
Y389
Identified Species:
29.05
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
Y389
R
W
N
E
W
L
N
Y
D
I
Y
I
P
D
L
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
F377
V
W
K
Q
R
L
E
F
D
I
N
I
C
D
L
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
F387
I
W
N
E
P
L
E
F
D
I
N
I
C
D
L
Dog
Lupus familis
XP_546764
1044
119674
F377
V
W
K
Q
R
L
E
F
D
I
N
V
C
D
L
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
Y389
R
W
N
E
W
L
N
Y
D
I
Y
I
P
D
L
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
F387
I
W
N
E
Q
L
E
F
D
I
N
I
C
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
Y389
R
W
N
E
W
L
M
Y
D
M
Y
I
P
D
L
Chicken
Gallus gallus
NP_001004410
1068
124270
Y389
R
W
N
E
W
L
S
Y
D
M
Y
I
P
D
L
Frog
Xenopus laevis
Q6AZN6
886
101139
T292
D
L
K
P
N
A
A
T
R
D
Q
L
N
I
I
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
Y389
R
W
N
E
W
L
T
Y
D
M
Y
I
P
D
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
F384
E
W
E
E
T
L
K
F
D
I
K
V
R
D
I
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
F484
W
N
K
E
M
Y
T
F
D
L
Y
M
K
D
M
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
K373
C
L
Y
K
V
R
L
K
A
G
V
F
H
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
H220
I
D
F
C
S
F
E
H
R
V
V
F
Q
E
S
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
Y281
N
D
P
I
E
E
K
Y
R
R
L
E
R
A
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
46.6
60
40
N.A.
100
60
N.A.
86.6
86.6
0
80
N.A.
N.A.
40
26.6
0
P-Site Similarity:
100
60
66.6
60
N.A.
100
66.6
N.A.
93.3
100
13.3
93.3
N.A.
N.A.
60
53.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
7
0
7
0
0
0
0
7
0
% A
% Cys:
7
0
0
7
0
0
0
0
0
0
0
0
27
0
0
% C
% Asp:
7
14
0
0
0
0
0
0
74
7
0
0
0
74
7
% D
% Glu:
7
0
7
60
7
7
34
0
0
0
0
7
0
7
0
% E
% Phe:
0
0
7
0
0
7
0
40
0
0
0
14
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% H
% Ile:
20
0
0
7
0
0
0
0
0
47
0
54
0
7
20
% I
% Lys:
0
0
27
7
0
0
14
7
0
0
7
0
7
0
0
% K
% Leu:
0
14
0
0
0
67
7
0
0
7
7
7
0
0
54
% L
% Met:
0
0
0
0
7
0
7
0
0
20
0
7
0
0
7
% M
% Asn:
7
7
47
0
7
0
14
0
0
0
27
0
7
0
0
% N
% Pro:
0
0
7
7
7
0
0
0
0
0
0
0
34
0
0
% P
% Gln:
0
0
0
14
7
0
0
0
0
0
7
0
7
0
0
% Q
% Arg:
34
0
0
0
14
7
0
0
20
7
0
0
14
0
0
% R
% Ser:
0
0
0
0
7
0
7
0
0
0
0
0
0
0
14
% S
% Thr:
0
0
0
0
7
0
14
7
0
0
0
0
0
0
0
% T
% Val:
14
0
0
0
7
0
0
0
0
7
14
14
0
0
0
% V
% Trp:
7
67
0
0
34
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
7
0
40
0
0
40
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _