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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
21.52
Human Site:
T727
Identified Species:
33.81
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
T727
K
Q
E
K
K
D
E
T
Q
K
V
Q
M
K
F
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
P707
K
L
S
S
Q
K
T
P
K
P
Q
T
K
E
L
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
V731
S
L
I
K
L
N
A
V
K
L
N
R
A
K
G
Dog
Lupus familis
XP_546764
1044
119674
T707
K
V
S
S
Q
K
T
T
K
P
Q
T
K
E
L
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
T727
K
Q
E
K
K
D
E
T
Q
K
V
Q
M
K
F
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
M731
S
L
I
K
L
N
A
M
K
L
N
R
A
K
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
T727
K
Q
E
K
K
D
E
T
Q
K
V
Q
M
K
F
Chicken
Gallus gallus
NP_001004410
1068
124270
T727
K
Q
E
K
K
D
E
T
Q
K
V
Q
M
K
F
Frog
Xenopus laevis
Q6AZN6
886
101139
E595
E
P
I
P
L
P
L
E
P
Q
V
K
I
R
G
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
T727
K
Q
E
K
K
D
E
T
Q
K
V
Q
M
K
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
D731
E
Q
I
K
Q
R
K
D
R
K
A
A
L
Q
G
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
A821
K
G
M
P
K
D
V
A
T
M
K
L
R
D
E
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
Q712
K
S
K
Q
A
K
Q
Q
D
K
G
E
I
R
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
T523
E
P
I
R
S
P
L
T
P
N
V
L
I
K
G
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
D584
R
P
I
A
L
P
L
D
P
D
V
L
I
C
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
6.6
13.3
13.3
N.A.
100
13.3
N.A.
100
100
6.6
100
N.A.
N.A.
20
20
13.3
P-Site Similarity:
100
26.6
33.3
33.3
N.A.
100
33.3
N.A.
100
100
40
100
N.A.
N.A.
60
20
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
7
0
14
7
0
0
7
7
14
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
0
0
0
0
0
40
0
14
7
7
0
0
0
7
14
% D
% Glu:
20
0
34
0
0
0
34
7
0
0
0
7
0
14
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
34
% F
% Gly:
0
7
0
0
0
0
0
0
0
0
7
0
0
0
34
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
40
0
0
0
0
0
0
0
0
0
27
0
0
% I
% Lys:
60
0
7
54
40
20
7
0
27
47
7
7
14
54
0
% K
% Leu:
0
20
0
0
27
0
20
0
0
14
0
20
7
0
14
% L
% Met:
0
0
7
0
0
0
0
7
0
7
0
0
34
0
0
% M
% Asn:
0
0
0
0
0
14
0
0
0
7
14
0
0
0
0
% N
% Pro:
0
20
0
14
0
20
0
7
20
14
0
0
0
0
0
% P
% Gln:
0
40
0
7
20
0
7
7
34
7
14
34
0
7
0
% Q
% Arg:
7
0
0
7
0
7
0
0
7
0
0
14
7
14
0
% R
% Ser:
14
7
14
14
7
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
14
47
7
0
0
14
0
0
0
% T
% Val:
0
7
0
0
0
0
7
7
0
0
54
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _