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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
12.42
Human Site:
T560
Identified Species:
19.52
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
T560
S
H
R
H
Y
C
V
T
I
P
E
I
L
P
K
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
H541
L
R
H
E
V
Q
E
H
F
P
E
A
L
A
R
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
I568
L
R
Q
D
C
R
E
I
F
P
Q
S
L
P
K
Dog
Lupus familis
XP_546764
1044
119674
R541
M
R
H
E
V
Q
E
R
F
P
E
A
L
A
R
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
T560
S
H
R
H
Y
C
V
T
I
P
E
I
L
P
K
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
N568
L
R
Q
D
C
R
E
N
F
P
Q
S
L
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
T560
S
H
R
H
Y
C
V
T
T
P
E
I
L
P
K
Chicken
Gallus gallus
NP_001004410
1068
124270
N560
S
H
R
H
Y
C
V
N
T
P
E
I
L
P
K
Frog
Xenopus laevis
Q6AZN6
886
101139
T439
T
S
G
I
N
P
E
T
D
S
S
Q
I
L
S
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
N560
R
H
R
Q
Y
C
V
N
I
P
E
I
L
P
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
L567
T
L
R
H
H
C
L
L
E
I
P
T
L
L
A
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
E647
R
R
Y
I
Q
K
Q
E
P
D
L
L
I
V
L
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
T543
S
D
D
N
P
F
E
T
P
S
E
Q
A
L
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
V367
P
L
F
E
S
E
E
V
R
A
Y
A
V
S
V
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
S428
T
F
S
D
K
S
N
S
E
F
T
I
V
D
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
20
26.6
20
N.A.
100
26.6
N.A.
93.3
86.6
6.6
80
N.A.
N.A.
26.6
0
20
P-Site Similarity:
100
26.6
40
26.6
N.A.
100
40
N.A.
93.3
86.6
20
80
N.A.
N.A.
46.6
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
7
0
20
7
14
14
% A
% Cys:
0
0
0
0
14
40
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
20
0
0
0
0
7
7
0
0
0
7
0
% D
% Glu:
0
0
0
20
0
7
47
7
14
0
54
0
0
0
7
% E
% Phe:
0
7
7
0
0
7
0
0
27
7
0
0
0
0
0
% F
% Gly:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
34
14
34
7
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
14
0
0
0
7
20
7
0
40
14
0
0
% I
% Lys:
0
0
0
0
7
7
0
0
0
0
0
0
0
0
47
% K
% Leu:
20
14
0
0
0
0
7
7
0
0
7
7
67
20
7
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
7
0
7
20
0
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
7
7
0
0
14
60
7
0
0
47
0
% P
% Gln:
0
0
14
7
7
14
7
0
0
0
14
14
0
0
0
% Q
% Arg:
14
34
40
0
0
14
0
7
7
0
0
0
0
0
14
% R
% Ser:
34
7
7
0
7
7
0
7
0
14
7
14
0
7
7
% S
% Thr:
20
0
0
0
0
0
0
34
14
0
7
7
0
0
0
% T
% Val:
0
0
0
0
14
0
34
7
0
0
0
0
14
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
34
0
0
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _