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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
17.88
Human Site:
T433
Identified Species:
28.1
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
T433
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
K429
N
L
M
L
F
D
Y
K
D
Q
L
K
T
G
E
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
K449
N
T
M
V
F
D
F
K
G
Q
L
R
T
G
D
Dog
Lupus familis
XP_546764
1044
119674
K429
N
L
M
L
F
D
Y
K
D
Q
L
K
T
G
E
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
T433
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
K449
N
T
M
V
F
D
F
K
G
Q
L
R
S
G
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
T433
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
Chicken
Gallus gallus
NP_001004410
1068
124270
T433
N
I
N
M
F
D
Y
T
D
T
L
V
S
G
K
Frog
Xenopus laevis
Q6AZN6
886
101139
E327
R
S
Y
L
T
S
Q
E
K
A
L
T
K
F
L
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
T433
N
V
N
L
F
D
Y
T
H
T
L
V
S
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
K440
N
T
T
I
Y
D
F
K
S
Q
L
K
T
G
A
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
R526
N
M
S
L
T
D
W
R
D
E
L
R
Q
G
Q
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
P413
D
I
N
V
S
N
L
P
R
M
A
K
L
C
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
N255
D
T
E
L
G
K
T
N
P
S
E
N
K
Q
L
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
G316
K
I
I
N
Y
P
P
G
T
K
L
T
A
H
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
53.3
33.3
53.3
N.A.
100
40
N.A.
100
93.3
13.3
86.6
N.A.
N.A.
26.6
40
13.3
P-Site Similarity:
100
73.3
53.3
73.3
N.A.
100
53.3
N.A.
100
100
13.3
93.3
N.A.
N.A.
53.3
66.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
7
7
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
14
0
0
0
0
74
0
0
47
0
0
0
0
0
14
% D
% Glu:
0
0
7
0
0
0
0
7
0
7
7
0
0
0
20
% E
% Phe:
0
0
0
0
60
0
20
0
0
0
0
0
0
7
0
% F
% Gly:
0
0
0
0
7
0
0
7
14
0
0
0
0
74
0
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% H
% Ile:
0
40
7
7
0
0
0
0
0
0
0
0
0
0
7
% I
% Lys:
7
0
0
0
0
7
0
34
7
7
0
27
14
0
34
% K
% Leu:
0
14
0
60
0
0
7
0
0
0
87
0
7
0
14
% L
% Met:
0
7
27
7
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
74
0
40
7
0
7
0
7
0
0
0
7
0
0
0
% N
% Pro:
0
0
0
0
0
7
7
7
7
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
7
0
0
34
0
0
7
7
7
% Q
% Arg:
7
0
0
0
0
0
0
7
7
0
0
20
0
0
0
% R
% Ser:
0
7
7
0
7
7
0
0
7
7
0
0
40
0
0
% S
% Thr:
0
27
7
0
14
0
7
34
7
34
0
14
27
0
0
% T
% Val:
0
7
0
20
0
0
0
0
0
0
0
34
0
0
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
14
0
47
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _