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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
21.1
Human Site:
S6
Identified Species:
33.15
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
S6
_
_
M
P
P
R
P
S
S
G
E
L
W
G
I
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
D6
_
_
M
P
P
G
V
D
C
P
M
E
F
W
T
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
A10
F
S
F
I
M
P
P
A
M
A
D
I
L
D
I
Dog
Lupus familis
XP_546764
1044
119674
D6
_
_
M
P
P
G
V
D
C
P
M
E
F
W
T
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
S6
_
_
M
P
P
R
P
S
S
G
E
L
W
G
I
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
D13
I
M
P
P
A
M
A
D
T
L
D
I
W
A
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
S6
_
_
M
P
P
R
P
S
S
G
E
L
W
G
I
Chicken
Gallus gallus
NP_001004410
1068
124270
S6
_
_
M
P
P
R
P
S
S
G
E
L
W
G
I
Frog
Xenopus laevis
Q6AZN6
886
101139
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
S6
_
_
M
P
P
R
P
S
S
G
E
L
W
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
S6
_
_
M
V
H
I
P
S
A
Y
T
Y
N
F
W
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
N30
L
I
A
G
H
G
R
N
S
R
R
I
S
Q
M
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
S13
V
P
N
L
D
Q
W
S
E
G
D
L
H
A
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
23
13.3
23
N.A.
100
13.3
N.A.
100
100
0
100
N.A.
N.A.
23
6.6
20
P-Site Similarity:
100
30.7
33.3
30.7
N.A.
100
46.6
N.A.
100
100
0
100
N.A.
N.A.
30.7
33.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
7
0
7
7
7
7
0
0
0
14
0
% A
% Cys:
0
0
0
0
0
0
0
0
14
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
20
0
0
20
0
0
7
0
% D
% Glu:
0
0
0
0
0
0
0
0
7
0
34
14
0
0
0
% E
% Phe:
7
0
7
0
0
0
0
0
0
0
0
0
14
7
0
% F
% Gly:
0
0
0
7
0
20
0
0
0
40
0
0
0
34
0
% G
% His:
0
0
0
0
14
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
7
7
0
7
0
7
0
0
0
0
0
20
0
0
40
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
7
0
0
7
0
0
0
0
0
7
0
40
7
0
0
% L
% Met:
0
7
54
0
7
7
0
0
7
0
14
0
0
0
7
% M
% Asn:
0
0
7
0
0
0
0
7
0
0
0
0
7
0
7
% N
% Pro:
0
7
7
54
47
7
47
0
0
14
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
0
0
0
0
0
0
0
7
0
% Q
% Arg:
0
0
0
0
0
34
7
0
0
7
7
0
0
0
0
% R
% Ser:
0
7
0
0
0
0
0
47
40
0
0
0
7
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
7
0
7
0
0
0
14
% T
% Val:
7
0
0
7
0
0
14
0
0
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
40
14
7
% W
% Tyr:
0
0
0
0
0
0
0
0
0
7
0
7
0
0
0
% Y
% Spaces:
54
54
0
0
0
0
0
0
0
0
0
0
0
0
0
% _