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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
0
Human Site:
S535
Identified Species:
0
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
S535
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
E516
L
Q
L
R
E
I
L
E
R
R
G
S
G
E
L
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
D543
P
V
L
K
E
I
L
D
R
D
P
L
S
Q
L
Dog
Lupus familis
XP_546764
1044
119674
E516
L
Q
L
R
E
I
L
E
R
R
G
S
G
E
L
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
C535
K
E
Q
L
R
A
L
C
T
R
D
P
L
S
E
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
D543
A
V
L
K
E
I
L
D
R
D
P
L
S
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
C535
K
E
Q
L
R
A
I
C
T
R
D
P
L
S
E
Chicken
Gallus gallus
NP_001004410
1068
124270
C535
K
E
Q
L
R
A
I
C
T
R
D
P
L
S
E
Frog
Xenopus laevis
Q6AZN6
886
101139
G414
N
F
E
D
I
K
S
G
L
E
P
T
K
K
D
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
G535
I
E
Q
L
R
Q
L
G
N
R
D
P
L
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
A542
L
E
Q
L
R
L
L
A
D
R
D
P
L
H
E
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
H622
L
Q
M
L
V
K
K
H
E
S
G
I
V
L
E
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
V518
E
Q
Y
R
Q
G
S
V
S
Y
P
T
F
D
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
L342
E
A
K
Q
A
I
Q
L
M
Y
K
W
E
M
I
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
L403
K
K
A
S
D
K
E
L
E
L
Y
L
L
Q
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
6.6
0
6.6
N.A.
80
0
N.A.
86.6
86.6
0
60
N.A.
N.A.
53.3
13.3
0
P-Site Similarity:
100
26.6
13.3
26.6
N.A.
93.3
13.3
N.A.
93.3
93.3
13.3
73.3
N.A.
N.A.
73.3
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
0
7
27
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
20
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
7
0
0
14
7
14
40
0
0
7
7
% D
% Glu:
14
40
7
0
27
0
7
14
14
7
0
0
7
14
47
% E
% Phe:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
0
0
0
7
0
14
0
0
20
0
14
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% H
% Ile:
7
0
0
0
7
34
20
0
0
0
0
7
0
0
7
% I
% Lys:
34
7
7
14
7
20
7
0
0
0
7
0
7
7
7
% K
% Leu:
27
0
27
47
0
7
47
14
7
7
0
20
47
7
34
% L
% Met:
0
0
7
0
0
0
0
0
7
0
0
0
0
7
0
% M
% Asn:
7
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
27
40
0
0
0
% P
% Gln:
0
27
40
7
7
7
7
0
0
0
0
0
0
20
0
% Q
% Arg:
0
0
0
20
34
0
0
0
27
54
0
0
0
0
0
% R
% Ser:
0
0
0
7
0
0
14
7
7
7
0
14
14
34
0
% S
% Thr:
0
0
0
0
0
0
0
0
27
0
0
14
0
0
0
% T
% Val:
0
14
0
0
7
0
0
7
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
14
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _