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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
15.76
Human Site:
S490
Identified Species:
24.76
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
S490
V
V
K
F
P
D
M
S
V
I
E
E
H
A
N
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
E477
A
L
L
I
C
L
P
E
V
A
P
H
P
V
Y
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
K500
I
K
F
P
E
N
K
K
Q
P
Y
Y
Y
P
P
Dog
Lupus familis
XP_546764
1044
119674
E477
A
L
V
I
C
L
P
E
V
A
P
Y
P
V
Y
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
S490
V
V
K
F
P
D
M
S
V
I
E
E
H
A
N
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
K499
H
I
K
F
P
E
N
K
K
Q
P
Y
Y
Y
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
T490
P
V
K
F
P
D
M
T
V
I
E
E
H
A
N
Chicken
Gallus gallus
NP_001004410
1068
124270
T490
P
V
K
F
P
D
M
T
V
I
E
E
H
A
N
Frog
Xenopus laevis
Q6AZN6
886
101139
T375
S
S
H
F
T
N
P
T
V
R
R
Y
A
V
A
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
A490
P
V
K
F
P
D
M
A
T
I
E
D
H
A
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
P499
K
E
K
S
V
L
Y
P
T
P
E
K
M
V
E
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
V574
I
S
S
Y
G
G
R
V
R
M
P
S
Q
G
Q
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
S468
L
T
F
F
D
Y
R
S
Q
L
R
S
G
P
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
E303
T
R
T
L
S
G
D
E
R
Q
L
L
W
K
F
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
D364
V
E
V
L
E
L
M
D
S
W
A
E
I
D
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
6.6
0
6.6
N.A.
100
20
N.A.
86.6
86.6
13.3
73.3
N.A.
N.A.
13.3
0
13.3
P-Site Similarity:
100
13.3
20
13.3
N.A.
100
40
N.A.
93.3
93.3
26.6
86.6
N.A.
N.A.
20
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
0
0
0
0
0
7
0
14
7
0
7
34
7
% A
% Cys:
0
0
0
0
14
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
34
7
7
0
0
0
7
0
7
0
% D
% Glu:
0
14
0
0
14
7
0
20
0
0
40
34
0
0
7
% E
% Phe:
0
0
14
54
0
0
0
0
0
0
0
0
0
0
7
% F
% Gly:
0
0
0
0
7
14
0
0
0
0
0
0
7
7
0
% G
% His:
7
0
7
0
0
0
0
0
0
0
0
7
34
0
7
% H
% Ile:
14
7
0
14
0
0
0
0
0
34
0
0
7
0
7
% I
% Lys:
7
7
47
0
0
0
7
14
7
0
0
7
0
7
0
% K
% Leu:
7
14
7
14
0
27
0
0
0
7
7
7
0
0
0
% L
% Met:
0
0
0
0
0
0
40
0
0
7
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
14
7
0
0
0
0
0
0
0
34
% N
% Pro:
20
0
0
7
40
0
20
7
0
14
27
0
14
14
14
% P
% Gln:
0
0
0
0
0
0
0
0
14
14
0
0
7
0
7
% Q
% Arg:
0
7
0
0
0
0
14
0
14
7
14
0
0
0
0
% R
% Ser:
7
14
7
7
7
0
0
20
7
0
0
14
0
0
0
% S
% Thr:
7
7
7
0
7
0
0
20
14
0
0
0
0
0
0
% T
% Val:
20
34
14
0
7
0
0
7
47
0
0
0
0
27
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
7
0
0
% W
% Tyr:
0
0
0
7
0
7
7
0
0
0
7
27
14
7
14
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _