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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
21.82
Human Site:
S268
Identified Species:
34.29
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
S268
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
C257
L
Y
G
S
Y
P
L
C
Q
F
Q
Y
I
C
S
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
I264
V
F
G
D
H
P
L
I
Q
F
Q
Y
I
R
N
Dog
Lupus familis
XP_546764
1044
119674
C257
L
Y
G
S
Y
P
L
C
Q
F
Q
Y
I
C
S
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
S268
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
I264
V
F
G
D
H
P
L
I
Q
F
Q
Y
I
R
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
S268
L
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
Chicken
Gallus gallus
NP_001004410
1068
124270
S268
L
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
Frog
Xenopus laevis
Q6AZN6
886
101139
S173
S
A
S
E
D
Q
M
S
R
L
A
K
L
T
K
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
S268
L
L
E
K
Y
P
I
S
Q
Y
K
Y
V
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
I256
L
I
G
D
Y
P
L
I
Q
F
S
Y
I
Q
D
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
L363
V
R
R
Q
S
L
V
L
K
D
Y
C
R
P
K
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
S249
L
L
G
G
H
P
L
S
K
Y
K
Y
P
V
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
I101
T
A
H
S
Q
L
A
I
T
V
W
D
V
S
C
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
D162
E
V
V
T
D
N
K
D
Q
E
N
L
N
K
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
46.6
40
46.6
N.A.
100
40
N.A.
93.3
93.3
6.6
80
N.A.
N.A.
40
0
53.3
P-Site Similarity:
100
60
66.6
60
N.A.
100
66.6
N.A.
93.3
93.3
33.3
93.3
N.A.
N.A.
60
20
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
0
0
0
0
7
0
0
0
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
14
0
0
0
7
0
14
7
% C
% Asp:
0
0
0
20
14
0
0
7
0
7
0
7
0
0
7
% D
% Glu:
7
0
34
7
0
0
0
0
0
7
0
0
0
0
0
% E
% Phe:
14
14
0
0
0
0
0
0
0
34
0
0
0
0
0
% F
% Gly:
0
0
40
7
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
7
0
20
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
7
27
0
0
0
0
60
0
0
% I
% Lys:
0
0
0
34
0
0
7
0
14
0
40
7
0
7
14
% K
% Leu:
47
40
0
0
0
14
67
7
0
7
0
7
7
0
0
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
0
0
0
7
0
7
0
14
% N
% Pro:
0
0
0
0
0
74
0
0
0
0
0
0
7
7
0
% P
% Gln:
0
0
0
7
7
7
0
0
74
0
27
0
0
7
0
% Q
% Arg:
0
7
7
0
0
0
0
0
7
0
0
0
7
47
0
% R
% Ser:
7
0
7
20
7
0
0
47
0
0
7
0
0
7
54
% S
% Thr:
7
0
0
7
0
0
0
0
7
0
0
0
0
7
0
% T
% Val:
20
7
7
0
0
0
7
0
0
7
0
0
14
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% W
% Tyr:
0
14
0
0
54
0
0
0
0
40
7
74
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _