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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HTR2B All Species: 1.21
Human Site: T36 Identified Species: 2.67
UniProt: P41595 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.4
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P41595 NP_000858.3 481 54298 T36 S N W S G L Q T E S I P E E M
Chimpanzee Pan troglodytes Q5IS66 458 51816 D42 T D I F N T S D G G R F K F P
Rhesus Macaque Macaca mulatta P50128 471 52585 A37 N D F N S G E A N T S D A F N
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q02152 479 53606 D36 N R S G L E T D S V A E E M K
Rat Rattus norvegicus P30994 479 53633 E36 D R S G L K A E S A A E E M K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508933 505 56299 L58 S F P N G T G L S S Q L I T E
Chicken Gallus gallus XP_425628 468 52653 E36 R N V Y G P G E I N V S H F C
Frog Xenopus laevis Q98998 408 45769
Zebra Danio Brachydanio rerio Q90WY4 388 43978
Tiger Blowfish Takifugu rubipres O42385 423 46982 S15 S N D S N A T S G Y S D T A A
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O02213 455 50851 P38 V S T T T L P P L D I P M T S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.9 44 N.A. N.A. 83.3 81.6 N.A. 75.6 45.1 22.8 25.1 21.6 N.A. N.A. 22.2 N.A.
Protein Similarity: 100 60.5 62.1 N.A. N.A. 90.4 88.5 N.A. 82.3 61.7 38.8 42.2 39.9 N.A. N.A. 43 N.A.
P-Site Identity: 100 0 0 N.A. N.A. 6.6 6.6 N.A. 20 13.3 0 0 20 N.A. N.A. 20 N.A.
P-Site Similarity: 100 20 40 N.A. N.A. 13.3 13.3 N.A. 26.6 26.6 0 0 26.6 N.A. N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 10 10 0 10 19 0 10 10 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 10 19 10 0 0 0 0 19 0 10 0 19 0 0 0 % D
% Glu: 0 0 0 0 0 10 10 19 10 0 0 19 28 10 10 % E
% Phe: 0 10 10 10 0 0 0 0 0 0 0 10 0 28 0 % F
% Gly: 0 0 0 19 28 10 19 0 19 10 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 10 0 19 0 10 0 0 % I
% Lys: 0 0 0 0 0 10 0 0 0 0 0 0 10 0 19 % K
% Leu: 0 0 0 0 19 19 0 10 10 0 0 10 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 10 19 10 % M
% Asn: 19 28 0 19 19 0 0 0 10 10 0 0 0 0 10 % N
% Pro: 0 0 10 0 0 10 10 10 0 0 0 19 0 0 10 % P
% Gln: 0 0 0 0 0 0 10 0 0 0 10 0 0 0 0 % Q
% Arg: 10 19 0 0 0 0 0 0 0 0 10 0 0 0 0 % R
% Ser: 28 10 19 19 10 0 10 10 28 19 19 10 0 0 10 % S
% Thr: 10 0 10 10 10 19 19 10 0 10 0 0 10 19 0 % T
% Val: 10 0 10 0 0 0 0 0 0 10 10 0 0 0 0 % V
% Trp: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 0 0 0 0 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _