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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR2B
All Species:
12.12
Human Site:
S312
Identified Species:
26.67
UniProt:
P41595
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41595
NP_000858.3
481
54298
S312
T
S
T
I
G
K
K
S
V
Q
T
I
S
N
E
Chimpanzee
Pan troglodytes
Q5IS66
458
51816
R297
K
K
K
E
R
R
P
R
G
T
M
Q
A
I
N
Rhesus Macaque
Macaca mulatta
P50128
471
52585
S290
F
L
P
Q
S
S
L
S
S
E
K
L
F
Q
R
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q02152
479
53606
S311
M
S
S
V
G
K
R
S
A
Q
T
I
S
N
E
Rat
Rattus norvegicus
P30994
479
53633
P311
M
S
S
A
G
K
K
P
A
Q
T
I
S
N
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508933
505
56299
S336
M
S
T
L
G
K
K
S
V
Q
T
L
T
N
E
Chicken
Gallus gallus
XP_425628
468
52653
L297
E
K
L
F
Q
R
S
L
N
R
D
M
G
T
S
Frog
Xenopus laevis
Q98998
408
45769
K247
S
Q
Q
S
P
K
E
K
Q
R
G
A
Q
Q
E
Zebra Danio
Brachydanio rerio
Q90WY4
388
43978
P227
V
G
K
K
E
N
D
P
H
E
K
L
N
G
I
Tiger Blowfish
Takifugu rubipres
O42385
423
46982
R262
S
P
A
V
F
H
K
R
A
N
G
D
A
V
S
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O02213
455
50851
T292
S
S
R
V
G
E
K
T
P
L
V
I
A
D
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.9
44
N.A.
N.A.
83.3
81.6
N.A.
75.6
45.1
22.8
25.1
21.6
N.A.
N.A.
22.2
N.A.
Protein Similarity:
100
60.5
62.1
N.A.
N.A.
90.4
88.5
N.A.
82.3
61.7
38.8
42.2
39.9
N.A.
N.A.
43
N.A.
P-Site Identity:
100
0
6.6
N.A.
N.A.
66.6
66.6
N.A.
73.3
0
13.3
0
6.6
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
100
13.3
20
N.A.
N.A.
86.6
73.3
N.A.
93.3
20
33.3
20
26.6
N.A.
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
10
0
0
0
0
28
0
0
10
28
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
10
0
0
0
10
10
0
10
0
% D
% Glu:
10
0
0
10
10
10
10
0
0
19
0
0
0
0
46
% E
% Phe:
10
0
0
10
10
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
10
0
0
46
0
0
0
10
0
19
0
10
10
10
% G
% His:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
0
0
0
0
37
0
10
10
% I
% Lys:
10
19
19
10
0
46
46
10
0
0
19
0
0
0
0
% K
% Leu:
0
10
10
10
0
0
10
10
0
10
0
28
0
0
0
% L
% Met:
28
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
10
10
0
0
10
37
10
% N
% Pro:
0
10
10
0
10
0
10
19
10
0
0
0
0
0
0
% P
% Gln:
0
10
10
10
10
0
0
0
10
37
0
10
10
19
0
% Q
% Arg:
0
0
10
0
10
19
10
19
0
19
0
0
0
0
10
% R
% Ser:
28
46
19
10
10
10
10
37
10
0
0
0
28
0
19
% S
% Thr:
10
0
19
0
0
0
0
10
0
10
37
0
10
10
0
% T
% Val:
10
0
0
28
0
0
0
0
19
0
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _