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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KDM5C
All Species:
38.18
Human Site:
Y749
Identified Species:
84
UniProt:
P41229
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41229
NP_001140174.1
1560
175720
Y749
S
S
R
Q
Y
L
R
Y
R
Y
T
L
D
E
L
Chimpanzee
Pan troglodytes
Q5XUN4
1535
173724
Y739
S
S
R
Q
Y
L
R
Y
R
Y
T
L
D
E
L
Rhesus Macaque
Macaca mulatta
XP_001090508
1411
159177
Y749
S
S
R
Q
Y
L
R
Y
R
Y
T
L
D
E
L
Dog
Lupus familis
XP_854690
1767
200598
Y718
M
Q
K
K
C
L
R
Y
R
Y
P
L
E
D
L
Cat
Felis silvestris
Mouse
Mus musculus
P41230
1554
175294
Y749
S
S
R
Q
Y
L
R
Y
R
Y
T
L
D
E
L
Rat
Rattus norvegicus
XP_001064297
1551
174906
Y749
S
S
R
Q
Y
L
R
Y
R
Y
T
L
D
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506982
1438
162538
Y741
S
S
K
Q
Y
L
R
Y
R
Y
T
L
D
E
L
Chicken
Gallus gallus
Q5F3R2
1522
173443
Y709
T
Y
Q
Y
K
L
G
Y
R
Y
T
L
E
E
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6IQX0
1503
171080
Y720
I
S
N
Y
T
L
N
Y
R
F
T
L
D
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VMJ7
1838
203974
Y872
P
E
K
H
T
L
I
Y
R
Y
T
L
D
E
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23541
1477
170773
Y751
T
K
D
Y
R
Y
Q
Y
R
F
E
L
D
Q
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
84.6
89.5
49
N.A.
95
94.8
N.A.
78.6
47.3
N.A.
45.3
N.A.
34.2
N.A.
25
N.A.
Protein Similarity:
100
90.3
90.1
63.6
N.A.
96.4
96.2
N.A.
83.5
64.2
N.A.
62.2
N.A.
48.7
N.A.
43.4
N.A.
P-Site Identity:
100
100
100
46.6
N.A.
100
100
N.A.
93.3
53.3
N.A.
53.3
N.A.
53.3
N.A.
33.3
N.A.
P-Site Similarity:
100
100
100
73.3
N.A.
100
100
N.A.
100
73.3
N.A.
66.6
N.A.
66.6
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
0
0
0
0
0
0
0
82
19
0
% D
% Glu:
0
10
0
0
0
0
0
0
0
0
10
0
19
73
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
10
28
10
10
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
91
0
0
0
0
0
100
0
0
91
% L
% Met:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
10
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% P
% Gln:
0
10
10
55
0
0
10
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
46
0
10
0
64
0
100
0
0
0
0
0
0
% R
% Ser:
55
64
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
19
0
0
0
19
0
0
0
0
0
82
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
28
55
10
0
100
0
82
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _