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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
29.7
Human Site:
Y336
Identified Species:
50.26
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
Y336
S
I
S
L
D
F
T
Y
P
S
L
E
E
S
I
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
Y336
S
I
S
L
D
F
T
Y
P
S
L
E
E
S
I
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
Y336
S
I
S
L
D
F
T
Y
P
S
L
E
E
S
V
Dog
Lupus familis
XP_535474
1116
127497
Y336
S
I
S
L
D
F
T
Y
P
S
L
E
E
S
V
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
Y336
S
V
S
L
D
F
T
Y
P
S
L
E
E
P
V
Rat
Rattus norvegicus
NP_001099972
1081
122532
V330
S
R
P
E
E
V
S
V
S
L
D
F
T
Y
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
Y332
S
I
S
L
D
F
T
Y
P
S
L
E
E
P
A
Chicken
Gallus gallus
XP_413830
1116
127997
Y336
T
V
S
L
D
F
T
Y
P
S
L
E
E
P
V
Frog
Xenopus laevis
NP_001080551
1063
120542
Y332
S
L
S
L
D
F
N
Y
P
S
L
E
E
P
T
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
N329
P
S
T
L
P
Q
L
N
F
T
Y
P
S
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
A184
S
H
L
T
Y
Y
C
A
F
N
V
P
E
E
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
P324
N
L
L
D
F
E
Y
P
V
F
D
D
D
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
D198
A
H
I
W
D
Y
F
D
K
R
K
N
G
L
L
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
I214
M
E
I
L
L
I
D
I
R
S
R
L
E
F
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
93.3
93.3
N.A.
80
6.6
N.A.
86.6
73.3
73.3
6.6
N.A.
13.3
N.A.
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
20
N.A.
86.6
93.3
80
20
N.A.
40
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
65
0
8
8
0
0
15
8
8
0
0
% D
% Glu:
0
8
0
8
8
8
0
0
0
0
0
58
72
8
8
% E
% Phe:
0
0
0
0
8
58
8
0
15
8
0
8
0
8
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% G
% His:
0
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
36
15
0
0
8
0
8
0
0
0
0
0
0
15
% I
% Lys:
0
0
0
0
0
0
0
0
8
0
8
0
0
8
0
% K
% Leu:
0
15
15
72
8
0
8
0
0
8
58
8
0
15
15
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
8
8
0
8
0
8
0
0
8
% N
% Pro:
8
0
8
0
8
0
0
8
58
0
0
15
0
29
15
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
8
8
8
0
0
0
0
% R
% Ser:
65
8
58
0
0
0
8
0
8
65
0
0
8
29
0
% S
% Thr:
8
0
8
8
0
0
50
0
0
8
0
0
8
0
8
% T
% Val:
0
15
0
0
0
8
0
8
8
0
8
0
0
0
29
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
15
8
58
0
0
8
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _