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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
39.39
Human Site:
T945
Identified Species:
66.67
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
T945
T
C
H
K
K
S
R
T
F
E
A
F
M
Y
L
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
T945
T
C
H
K
K
S
R
T
F
E
A
F
M
Y
L
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
T945
T
C
H
K
K
S
R
T
F
E
A
F
M
Y
L
Dog
Lupus familis
XP_535474
1116
127497
T943
T
C
H
K
K
S
R
T
F
E
A
F
M
Y
L
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
T907
T
C
R
R
R
S
R
T
F
E
A
F
M
Y
L
Rat
Rattus norvegicus
NP_001099972
1081
122532
T908
T
C
H
K
K
S
R
T
F
E
A
F
M
Y
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
T943
T
C
H
K
R
S
R
T
F
E
A
F
M
Y
L
Chicken
Gallus gallus
XP_413830
1116
127997
T943
T
C
H
K
K
S
R
T
F
E
A
F
M
Y
L
Frog
Xenopus laevis
NP_001080551
1063
120542
T891
T
C
Q
K
K
S
R
T
F
E
A
F
M
Y
L
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
T908
S
C
Q
H
K
S
R
T
F
E
T
F
M
Y
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
P733
S
N
L
S
L
E
L
P
P
N
S
N
V
C
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
K1020
S
C
N
N
K
S
V
K
F
E
A
F
M
Y
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
I747
K
K
T
R
Q
E
S
I
S
L
F
S
C
L
E
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
I763
N
S
R
N
N
I
T
I
E
D
C
F
R
E
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
100
100
N.A.
80
100
N.A.
93.3
100
93.3
73.3
N.A.
0
N.A.
N.A.
66.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
100
N.A.
100
100
93.3
80
N.A.
20
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
72
0
0
0
0
% A
% Cys:
0
79
0
0
0
0
0
0
0
0
8
0
8
8
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
15
0
0
8
79
0
0
0
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
79
0
8
86
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
50
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
15
0
0
0
0
0
0
0
% I
% Lys:
8
8
0
58
65
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
8
0
8
0
8
0
0
8
0
0
0
8
79
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
79
0
0
% M
% Asn:
8
8
8
15
8
0
0
0
0
8
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% P
% Gln:
0
0
15
0
8
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
15
15
15
0
72
0
0
0
0
0
8
0
0
% R
% Ser:
22
8
0
8
0
79
8
0
8
0
8
8
0
0
0
% S
% Thr:
65
0
8
0
0
0
8
72
0
0
8
0
0
0
0
% T
% Val:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
79
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _