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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
13.64
Human Site:
T454
Identified Species:
23.08
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
T454
K
P
V
V
F
S
P
T
L
M
L
T
D
E
E
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
T454
K
P
V
V
F
S
P
T
L
M
L
T
D
E
E
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
T454
K
P
V
V
F
S
P
T
L
M
L
T
D
E
E
Dog
Lupus familis
XP_535474
1116
127497
T454
K
P
V
F
P
P
P
T
A
M
L
T
D
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
E454
P
T
T
M
L
T
D
E
E
K
A
R
I
H
Q
Rat
Rattus norvegicus
NP_001099972
1081
122532
A448
K
P
V
F
T
S
P
A
T
M
L
T
D
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
T450
F
D
P
T
A
V
L
T
E
E
E
K
S
R
I
Chicken
Gallus gallus
XP_413830
1116
127997
V454
P
L
L
D
A
K
S
V
L
T
E
E
E
K
S
Frog
Xenopus laevis
NP_001080551
1063
120542
D450
R
S
T
K
P
S
L
D
S
K
S
V
K
A
E
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
V447
D
R
S
K
K
P
S
V
I
P
P
S
S
S
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
P302
T
I
D
D
I
E
Y
P
S
I
H
D
I
T
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
G442
T
P
D
L
A
K
S
G
P
A
S
S
T
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
S316
G
N
T
C
F
M
N
S
A
L
Q
C
L
A
H
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
F332
G
R
Q
V
S
S
S
F
P
S
N
N
N
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
100
73.3
N.A.
0
73.3
N.A.
6.6
6.6
13.3
0
N.A.
0
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
73.3
N.A.
20
73.3
N.A.
6.6
26.6
20
20
N.A.
6.6
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
22
0
0
8
15
8
8
0
0
15
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
8
8
15
15
0
0
8
8
0
0
0
8
36
0
0
% D
% Glu:
0
0
0
0
0
8
0
8
15
8
15
8
8
36
43
% E
% Phe:
8
0
0
15
29
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
15
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
8
% H
% Ile:
0
8
0
0
8
0
0
0
8
8
0
0
15
8
8
% I
% Lys:
36
0
0
15
8
15
0
0
0
15
0
8
8
8
22
% K
% Leu:
0
8
8
8
8
0
15
0
29
8
36
0
8
0
0
% L
% Met:
0
0
0
8
0
8
0
0
0
36
0
0
0
0
8
% M
% Asn:
0
8
0
0
0
0
8
0
0
0
8
8
8
0
0
% N
% Pro:
15
43
8
0
15
15
36
8
15
8
8
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
8
% Q
% Arg:
8
15
0
0
0
0
0
0
0
0
0
8
0
8
0
% R
% Ser:
0
8
8
0
8
43
29
8
15
8
15
15
15
8
8
% S
% Thr:
15
8
22
8
8
8
0
36
8
8
0
36
8
15
0
% T
% Val:
0
0
36
29
0
8
0
15
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _