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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
14.24
Human Site:
T379
Identified Species:
24.1
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
T379
M
G
P
L
N
I
S
T
P
V
E
P
V
A
A
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
T379
M
G
P
L
N
I
S
T
P
V
E
P
V
A
A
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
T379
M
G
P
L
N
I
S
T
P
A
E
P
V
A
A
Dog
Lupus familis
XP_535474
1116
127497
A379
V
A
P
L
N
I
S
A
P
V
E
P
I
A
A
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
A379
L
R
L
S
T
Q
P
A
L
A
G
P
G
A
A
Rat
Rattus norvegicus
NP_001099972
1081
122532
R373
T
D
Q
D
G
K
P
R
P
L
V
Q
S
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
T375
T
G
P
L
N
P
P
T
P
G
G
P
V
A
A
Chicken
Gallus gallus
XP_413830
1116
127997
S379
L
K
S
L
N
R
P
S
V
E
G
A
A
V
P
Frog
Xenopus laevis
NP_001080551
1063
120542
V375
T
Q
K
T
E
E
P
V
H
V
I
Q
K
D
D
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
P372
E
P
A
T
N
T
P
P
L
A
H
P
T
N
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
W227
D
S
V
V
L
M
D
W
N
T
K
D
A
Q
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
Y367
G
Y
Q
N
R
M
F
Y
I
S
G
K
P
G
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
T241
S
Q
S
A
M
S
S
T
G
N
E
L
A
L
V
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
N257
K
S
L
I
T
S
P
N
S
E
I
K
M
F
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
93.3
73.3
N.A.
20
13.3
N.A.
66.6
13.3
6.6
13.3
N.A.
0
N.A.
N.A.
0
P-Site Similarity:
100
100
93.3
86.6
N.A.
26.6
20
N.A.
66.6
26.6
6.6
13.3
N.A.
20
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
8
0
0
0
15
0
22
0
8
22
50
43
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
8
0
0
8
0
0
0
0
8
0
8
8
% D
% Glu:
8
0
0
0
8
8
0
0
0
15
36
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% F
% Gly:
8
29
0
0
8
0
0
0
8
8
29
0
8
8
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% H
% Ile:
0
0
0
8
0
29
0
0
8
0
15
0
8
0
0
% I
% Lys:
8
8
8
0
0
8
0
0
0
0
8
15
8
0
0
% K
% Leu:
15
0
15
43
8
0
0
0
15
8
0
8
0
8
8
% L
% Met:
22
0
0
0
8
15
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
8
50
0
0
8
8
8
0
0
0
8
0
% N
% Pro:
0
8
36
0
0
8
50
8
43
0
0
50
8
0
15
% P
% Gln:
0
15
15
0
0
8
0
0
0
0
0
15
0
8
15
% Q
% Arg:
0
8
0
0
8
8
0
8
0
0
0
0
0
0
0
% R
% Ser:
8
15
15
8
0
15
36
8
8
8
0
0
8
0
0
% S
% Thr:
22
0
0
15
15
8
0
36
0
8
0
0
8
0
8
% T
% Val:
8
0
8
8
0
0
0
8
8
29
8
0
29
8
8
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _