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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
28.48
Human Site:
T273
Identified Species:
48.21
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
T273
K
D
L
Q
I
G
T
T
L
R
S
L
K
D
A
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
T273
K
D
L
Q
I
G
T
T
L
R
S
L
K
D
A
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
V273
K
D
L
Q
I
G
T
V
L
R
S
L
K
D
A
Dog
Lupus familis
XP_535474
1116
127497
T273
K
D
L
Q
L
G
T
T
L
R
S
L
K
D
A
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
T273
K
D
L
L
L
G
T
T
L
R
S
L
K
D
A
Rat
Rattus norvegicus
NP_001099972
1081
122532
D267
D
W
F
S
S
A
K
D
L
L
L
G
T
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
T269
K
D
L
L
L
G
T
T
L
R
S
L
K
D
A
Chicken
Gallus gallus
XP_413830
1116
127997
T273
E
D
L
N
I
G
T
T
L
R
S
L
K
D
A
Frog
Xenopus laevis
NP_001080551
1063
120542
T269
N
D
L
K
I
G
T
T
L
Q
S
L
K
D
A
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
R266
F
S
S
V
S
D
L
R
L
G
S
T
L
Q
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
I121
Q
H
Q
A
P
E
P
I
A
P
D
L
V
S
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
T261
Q
C
Q
R
A
D
S
T
L
A
I
V
E
A
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
C135
P
I
E
R
K
L
I
C
Q
G
F
Y
T
R
S
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
K151
T
L
L
E
T
L
L
K
D
E
N
I
A
K
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
93.3
93.3
N.A.
86.6
6.6
N.A.
86.6
86.6
80
13.3
N.A.
6.6
N.A.
N.A.
20
P-Site Similarity:
100
100
93.3
100
N.A.
93.3
6.6
N.A.
93.3
93.3
93.3
20
N.A.
13.3
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
8
0
0
8
8
0
0
8
8
65
% A
% Cys:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
8
58
0
0
0
15
0
8
8
0
8
0
0
58
0
% D
% Glu:
8
0
8
8
0
8
0
0
0
8
0
0
8
0
0
% E
% Phe:
8
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
0
58
0
0
0
15
0
8
0
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
36
0
8
8
0
0
8
8
0
0
8
% I
% Lys:
43
0
0
8
8
0
8
8
0
0
0
0
58
8
0
% K
% Leu:
0
8
65
15
22
15
15
0
79
8
8
65
8
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
8
0
0
0
0
0
0
8
0
0
0
8
% N
% Pro:
8
0
0
0
8
0
8
0
0
8
0
0
0
0
0
% P
% Gln:
15
0
15
29
0
0
0
0
8
8
0
0
0
8
0
% Q
% Arg:
0
0
0
15
0
0
0
8
0
50
0
0
0
8
0
% R
% Ser:
0
8
8
8
15
0
8
0
0
0
65
0
0
8
15
% S
% Thr:
8
0
0
0
8
0
58
58
0
0
0
8
15
8
0
% T
% Val:
0
0
0
8
0
0
0
8
0
0
0
8
8
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _