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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
12.73
Human Site:
T148
Identified Species:
21.54
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
T148
T
G
R
E
D
G
G
T
L
A
K
G
S
L
E
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
T148
T
G
R
E
D
G
G
T
L
A
K
G
S
L
E
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
T148
T
G
R
E
D
G
G
T
L
A
K
G
S
L
E
Dog
Lupus familis
XP_535474
1116
127497
T148
A
G
R
E
D
G
G
T
S
T
K
S
S
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
A148
M
G
R
E
D
S
G
A
A
A
K
R
S
V
E
Rat
Rattus norvegicus
NP_001099972
1081
122532
G142
Q
Q
K
R
Q
E
M
G
R
E
D
S
G
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
G144
K
Q
E
T
G
R
D
G
G
K
A
S
T
K
S
Chicken
Gallus gallus
XP_413830
1116
127997
S148
G
K
S
S
A
K
T
S
S
E
S
T
V
D
C
Frog
Xenopus laevis
NP_001080551
1063
120542
P144
K
L
F
P
K
D
F
P
E
D
V
P
S
Q
L
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
K141
R
E
E
R
T
E
K
K
D
G
R
A
S
P
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
G136
K
E
R
V
K
A
N
G
L
K
D
G
K
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
I10
I
P
N
S
D
F
M
I
E
N
G
V
C
D
F
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
L26
K
Y
L
T
I
A
Q
L
T
A
I
A
E
A
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
100
73.3
N.A.
60
0
N.A.
0
0
6.6
6.6
N.A.
0
N.A.
N.A.
20
P-Site Similarity:
100
100
100
73.3
N.A.
66.6
6.6
N.A.
6.6
6.6
6.6
20
N.A.
0
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
15
0
8
8
36
8
15
0
15
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% C
% Asp:
0
0
0
0
43
8
8
0
8
8
15
0
0
15
0
% D
% Glu:
0
15
15
36
0
15
0
0
15
15
0
0
8
0
36
% E
% Phe:
0
0
8
0
0
8
8
0
0
0
0
0
0
0
8
% F
% Gly:
8
36
0
0
8
29
36
22
8
8
8
29
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
8
0
0
8
0
0
8
0
0
0
0
% I
% Lys:
29
8
8
0
15
8
8
8
0
15
36
0
8
8
15
% K
% Leu:
0
8
8
0
0
0
0
8
29
0
0
0
0
29
8
% L
% Met:
8
0
0
0
0
0
15
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
8
0
0
8
0
0
0
0
0
% N
% Pro:
0
8
0
8
0
0
0
8
0
0
0
8
0
8
0
% P
% Gln:
8
15
0
0
8
0
8
0
0
0
0
0
0
8
8
% Q
% Arg:
8
0
43
15
0
8
0
0
8
0
8
8
0
0
0
% R
% Ser:
0
0
8
15
0
8
0
8
15
0
8
22
50
0
8
% S
% Thr:
22
0
0
15
8
0
8
29
8
8
0
8
8
8
0
% T
% Val:
0
0
0
8
0
0
0
0
0
0
8
8
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _