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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
34.85
Human Site:
S869
Identified Species:
58.97
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
S869
A
G
Y
S
Q
Q
D
S
Q
E
L
L
L
F
L
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
S869
A
G
Y
S
Q
Q
D
S
Q
E
L
L
L
F
L
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
S869
A
G
Y
S
Q
Q
D
S
Q
E
L
L
L
F
L
Dog
Lupus familis
XP_535474
1116
127497
S867
A
G
Y
S
Q
Q
D
S
Q
E
L
L
L
F
L
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
S831
A
G
S
S
Q
Q
D
S
Q
E
L
L
L
F
L
Rat
Rattus norvegicus
NP_001099972
1081
122532
S832
A
G
S
S
Q
Q
D
S
Q
E
L
L
L
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
S867
S
G
Y
S
Q
Q
D
S
Q
E
L
L
L
F
L
Chicken
Gallus gallus
XP_413830
1116
127997
S867
A
G
Y
S
Q
Q
D
S
Q
E
L
L
L
F
L
Frog
Xenopus laevis
NP_001080551
1063
120542
N835
E
D
L
N
K
A
D
N
R
K
R
Q
K
E
E
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
S832
S
S
Y
E
H
Q
D
S
Q
E
L
L
L
F
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
E678
L
H
V
P
R
Q
R
E
M
I
S
A
S
E
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
H942
R
K
H
V
G
H
H
H
D
S
Q
E
F
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
F692
T
D
E
R
G
L
N
F
K
P
L
Q
S
E
S
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
E708
I
A
S
S
I
E
W
E
R
F
L
T
T
D
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
93.3
100
6.6
73.3
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
100
40
80
N.A.
13.3
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
8
0
0
0
8
0
0
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
15
0
0
0
0
72
0
8
0
0
0
0
8
0
% D
% Glu:
8
0
8
8
0
8
0
15
0
65
0
8
0
22
8
% E
% Phe:
0
0
0
0
0
0
0
8
0
8
0
0
8
65
8
% F
% Gly:
0
58
0
0
15
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
8
8
0
8
8
8
8
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
0
8
0
0
8
0
0
0
8
8
0
0
8
0
8
% K
% Leu:
8
0
8
0
0
8
0
0
0
0
79
65
65
8
72
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
8
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
58
72
0
0
65
0
8
15
0
0
0
% Q
% Arg:
8
0
0
8
8
0
8
0
15
0
8
0
0
0
0
% R
% Ser:
15
8
22
65
0
0
0
65
0
8
8
0
15
0
8
% S
% Thr:
8
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% T
% Val:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
50
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _