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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
10.61
Human Site:
S597
Identified Species:
17.95
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
S597
H
T
S
V
T
G
D
S
G
S
G
K
P
F
K
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
S597
H
T
S
V
T
G
D
S
G
S
G
K
P
F
K
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
S597
H
T
S
A
T
G
D
S
G
S
S
K
P
F
K
Dog
Lupus familis
XP_535474
1116
127497
A596
H
A
S
V
A
G
D
A
N
S
G
K
P
V
K
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
C567
V
P
V
E
G
K
R
C
P
T
S
E
A
Q
K
Rat
Rattus norvegicus
NP_001099972
1081
122532
V560
H
D
A
S
D
A
K
V
S
V
E
G
K
R
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
P595
Q
A
S
G
M
E
E
P
S
S
S
K
H
V
R
Chicken
Gallus gallus
XP_413830
1116
127997
S595
R
R
V
L
G
D
V
S
P
N
K
Q
T
E
V
Frog
Xenopus laevis
NP_001080551
1063
120542
T569
E
E
D
K
S
D
V
T
V
K
D
S
C
E
E
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
K560
D
K
S
R
K
T
Q
K
D
T
P
A
D
A
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
N414
A
Q
D
Y
I
V
E
N
N
R
L
R
E
E
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
D632
S
S
K
K
V
A
D
D
S
S
N
E
P
A
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
D428
K
D
S
D
S
R
P
D
D
E
V
A
E
E
L
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
P444
S
P
L
P
L
H
S
P
D
P
V
K
G
N
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
86.6
66.6
N.A.
6.6
6.6
N.A.
20
6.6
0
6.6
N.A.
0
N.A.
N.A.
20
P-Site Similarity:
100
100
86.6
73.3
N.A.
20
13.3
N.A.
33.3
26.6
20
13.3
N.A.
20
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
15
8
8
8
15
0
8
0
0
0
15
8
15
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
8
% C
% Asp:
8
15
15
8
8
15
36
15
22
0
8
0
8
0
0
% D
% Glu:
8
8
0
8
0
8
15
0
0
8
8
15
15
29
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
22
0
% F
% Gly:
0
0
0
8
15
29
0
0
22
0
22
8
8
0
0
% G
% His:
36
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
8
8
15
8
8
8
8
0
8
8
43
8
0
36
% K
% Leu:
0
0
8
8
8
0
0
0
0
0
8
0
0
0
15
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
15
8
8
0
0
8
0
% N
% Pro:
0
15
0
8
0
0
8
15
15
8
8
0
36
0
8
% P
% Gln:
8
8
0
0
0
0
8
0
0
0
0
8
0
8
0
% Q
% Arg:
8
8
0
8
0
8
8
0
0
8
0
8
0
8
8
% R
% Ser:
15
8
50
8
15
0
8
29
22
43
22
8
0
0
8
% S
% Thr:
0
22
0
0
22
8
0
8
0
15
0
0
8
0
0
% T
% Val:
8
0
15
22
8
8
15
8
8
8
15
0
0
15
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _