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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
15.15
Human Site:
S389
Identified Species:
25.64
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
S389
E
P
V
A
A
S
K
S
D
V
S
P
I
I
Q
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
S389
E
P
V
A
A
S
K
S
D
V
S
P
I
I
Q
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
S389
E
P
V
A
A
S
K
S
D
V
S
P
I
I
Q
Dog
Lupus familis
XP_535474
1116
127497
S389
E
P
I
A
A
S
K
S
D
V
L
P
I
I
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
A389
G
P
G
A
A
P
R
A
E
A
S
P
I
I
Q
Rat
Rattus norvegicus
NP_001099972
1081
122532
P383
V
Q
S
A
L
A
G
P
S
V
A
P
K
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
S385
G
P
V
A
A
R
G
S
P
V
V
Q
A
T
S
Chicken
Gallus gallus
XP_413830
1116
127997
D389
G
A
A
V
P
K
P
D
S
S
F
V
V
N
P
Frog
Xenopus laevis
NP_001080551
1063
120542
P385
I
Q
K
D
D
P
V
P
E
V
H
T
D
S
V
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
P382
H
P
T
N
T
H
T
P
P
L
A
Q
P
T
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
N237
K
D
A
Q
P
A
T
N
T
A
I
S
T
L
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
Q377
G
K
P
G
Q
T
G
Q
T
G
Q
R
P
V
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
E251
E
L
A
L
V
P
L
E
P
S
R
S
S
V
T
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
N267
I
K
M
F
Q
S
R
N
L
F
K
F
I
I
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
100
86.6
N.A.
53.3
20
N.A.
40
0
6.6
6.6
N.A.
0
N.A.
N.A.
0
P-Site Similarity:
100
100
100
93.3
N.A.
73.3
40
N.A.
40
6.6
13.3
20
N.A.
26.6
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
22
50
43
15
0
8
0
15
15
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
8
8
0
0
8
29
0
0
0
8
0
0
% D
% Glu:
36
0
0
0
0
0
0
8
15
0
0
0
0
0
8
% E
% Phe:
0
0
0
8
0
0
0
0
0
8
8
8
0
0
0
% F
% Gly:
29
0
8
8
0
0
22
0
0
8
0
0
0
0
0
% G
% His:
8
0
0
0
0
8
0
0
0
0
8
0
0
0
0
% H
% Ile:
15
0
8
0
0
0
0
0
0
0
8
0
43
43
0
% I
% Lys:
8
15
8
0
0
8
29
0
0
0
8
0
8
0
0
% K
% Leu:
0
8
0
8
8
0
8
0
8
8
8
0
0
8
15
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
15
0
0
0
0
0
8
0
% N
% Pro:
0
50
8
0
15
22
8
22
22
0
0
43
15
0
8
% P
% Gln:
0
15
0
8
15
0
0
8
0
0
8
15
0
0
36
% Q
% Arg:
0
0
0
0
0
8
15
0
0
0
8
8
0
0
0
% R
% Ser:
0
0
8
0
0
36
0
36
15
15
29
15
8
8
8
% S
% Thr:
0
0
8
0
8
8
15
0
15
0
0
8
8
15
15
% T
% Val:
8
0
29
8
8
0
8
0
0
50
8
8
8
15
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _