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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
24.55
Human Site:
Y690
Identified Species:
45
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
Y690
F
Y
S
I
R
K
Q
Y
I
S
E
E
S
T
L
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
Y690
F
Y
S
I
R
K
Q
Y
I
S
E
E
S
T
L
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
H518
E
E
I
N
E
R
G
H
E
V
L
R
E
M
L
Dog
Lupus familis
XP_534219
757
84567
Y691
F
Y
S
I
R
K
Q
Y
I
S
E
E
S
T
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
Y694
F
Y
S
I
R
K
Q
Y
I
L
E
E
S
T
L
Rat
Rattus norvegicus
P97679
757
84522
Y691
F
Y
S
I
R
K
Q
Y
I
L
E
E
S
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
Y691
F
Y
S
I
R
K
Q
Y
I
I
D
E
T
N
L
Frog
Xenopus laevis
NP_001090545
750
84121
K684
S
N
F
Y
S
I
R
K
Q
Y
I
L
D
E
S
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
S659
V
E
C
S
H
F
Y
S
I
R
K
S
Y
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
R650
S
T
E
Q
P
C
F
R
N
I
C
R
E
T
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
S679
F
Y
R
I
Q
K
N
S
K
L
T
D
T
R
G
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
D681
K
E
K
A
T
D
I
D
V
E
M
E
D
E
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
P703
L
Y
I
P
D
M
V
P
K
V
D
T
S
D
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
100
6.6
100
N.A.
93.3
86.6
N.A.
N.A.
73.3
0
20
N.A.
N.A.
6.6
N.A.
26.6
P-Site Similarity:
100
100
20
100
N.A.
93.3
86.6
N.A.
N.A.
86.6
6.6
26.6
N.A.
N.A.
6.6
N.A.
46.6
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
13.3
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
20
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
16
% A
% Cys:
0
0
8
0
0
8
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
0
0
0
8
8
0
8
0
0
16
8
16
8
0
% D
% Glu:
8
24
8
0
8
0
0
0
8
8
39
54
16
16
0
% E
% Phe:
54
0
8
0
0
8
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
16
54
0
8
8
0
54
16
8
0
0
0
0
% I
% Lys:
8
0
8
0
0
54
0
8
16
0
8
0
0
0
0
% K
% Leu:
8
0
0
0
0
0
0
0
0
24
8
8
0
0
70
% L
% Met:
0
0
0
0
0
8
0
0
0
0
8
0
0
8
0
% M
% Asn:
0
8
0
8
0
0
8
0
8
0
0
0
0
8
0
% N
% Pro:
0
0
0
8
8
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
8
0
47
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
8
0
47
8
8
8
0
8
0
16
0
8
0
% R
% Ser:
16
0
47
8
8
0
0
16
0
24
0
8
47
0
8
% S
% Thr:
0
8
0
0
8
0
0
0
0
0
8
8
16
47
0
% T
% Val:
8
0
0
0
0
0
8
0
8
16
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
62
0
8
0
0
8
47
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _