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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
32.42
Human Site:
Y130
Identified Species:
59.44
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
Y130
K
C
A
Y
R
A
S
Y
S
D
G
K
L
K
A
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
Y130
K
C
A
Y
R
A
S
Y
S
D
G
K
L
K
A
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
Dog
Lupus familis
XP_534219
757
84567
Y130
K
C
A
Y
R
A
T
Y
S
D
G
K
L
K
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
Y130
K
C
A
Y
R
A
S
Y
S
D
G
K
L
Q
A
Rat
Rattus norvegicus
P97679
757
84522
Y130
K
C
A
Y
R
A
S
Y
S
D
G
K
L
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
Y130
K
C
A
Y
R
A
S
Y
S
D
G
K
I
K
A
Frog
Xenopus laevis
NP_001090545
750
84121
Y127
K
C
A
Y
R
A
S
Y
A
D
G
K
L
K
A
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
R124
A
D
A
K
C
A
Y
R
A
N
Y
C
D
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
S110
L
A
S
I
S
H
I
S
L
L
T
I
T
T
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
F127
K
C
A
Y
K
G
N
F
S
D
G
K
L
K
A
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
S122
E
D
L
Q
S
I
K
S
M
G
F
R
G
E
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
Y127
R
C
A
W
R
V
S
Y
A
E
G
K
M
L
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
100
0
93.3
N.A.
93.3
93.3
N.A.
N.A.
93.3
93.3
13.3
N.A.
N.A.
0
N.A.
73.3
P-Site Similarity:
100
100
0
100
N.A.
100
100
N.A.
N.A.
100
100
26.6
N.A.
N.A.
6.6
N.A.
93.3
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
6.6
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
N.A.
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
77
0
0
62
0
0
24
0
0
0
0
0
70
% A
% Cys:
0
70
0
0
8
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
16
0
0
0
0
0
0
0
62
0
0
8
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
0
8
0
0
0
8
8
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
0
0
0
8
70
0
8
8
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
8
8
0
0
0
0
8
8
0
0
% I
% Lys:
62
0
0
8
8
0
8
0
0
0
0
70
0
47
16
% K
% Leu:
8
0
8
0
0
0
0
0
8
8
0
0
54
8
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
0
0
0
0
0
16
0
% Q
% Arg:
8
0
0
0
62
0
0
8
0
0
0
8
0
0
0
% R
% Ser:
0
0
8
0
16
0
54
16
54
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
8
0
0
0
8
0
8
8
0
% T
% Val:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
62
0
0
8
62
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _