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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
33.94
Human Site:
T504
Identified Species:
62.22
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
T504
R
R
R
I
I
N
L
T
S
V
L
S
L
Q
E
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
T504
R
R
R
I
I
N
L
T
S
V
L
S
L
Q
E
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
F344
S
N
S
S
R
M
Y
F
T
Q
T
L
L
P
G
Dog
Lupus familis
XP_534219
757
84567
T505
R
R
R
I
I
N
L
T
S
V
L
S
L
Q
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
T508
R
R
R
I
I
N
L
T
S
V
L
S
L
Q
E
Rat
Rattus norvegicus
P97679
757
84522
T506
R
R
R
I
I
N
L
T
S
V
L
S
L
Q
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
T505
K
R
R
I
I
N
L
T
S
V
L
T
L
Q
E
Frog
Xenopus laevis
NP_001090545
750
84121
T500
R
R
R
I
I
N
L
T
S
I
L
S
L
Q
K
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
D485
T
S
I
K
G
L
R
D
Q
I
E
L
Q
T
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
L474
S
S
P
S
T
S
D
L
R
E
V
K
L
T
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
T493
K
R
K
E
I
Q
L
T
S
V
L
E
L
Q
K
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
C486
L
L
D
I
V
R
N
C
T
Y
I
G
M
A
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
T512
E
R
V
N
V
N
L
T
S
I
K
K
L
R
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
100
6.6
100
N.A.
100
100
N.A.
N.A.
86.6
86.6
0
N.A.
N.A.
6.6
N.A.
60
P-Site Similarity:
100
100
13.3
100
N.A.
100
100
N.A.
N.A.
100
100
6.6
N.A.
N.A.
20
N.A.
80
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
6.6
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
40
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
8
8
0
0
0
0
0
0
8
% D
% Glu:
8
0
0
8
0
0
0
0
0
8
8
8
0
0
54
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
8
62
62
0
0
0
0
24
8
0
0
0
0
% I
% Lys:
16
0
8
8
0
0
0
0
0
0
8
16
0
0
16
% K
% Leu:
8
8
0
0
0
8
70
8
0
0
62
16
85
0
0
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
8
0
8
0
62
8
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
8
0
0
8
8
0
0
8
62
0
% Q
% Arg:
47
70
54
0
8
8
8
0
8
0
0
0
0
8
0
% R
% Ser:
16
16
8
16
0
8
0
0
70
0
0
47
0
0
8
% S
% Thr:
8
0
0
0
8
0
0
70
16
0
8
8
0
16
0
% T
% Val:
0
0
8
0
16
0
0
0
0
54
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _