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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
20.3
Human Site:
T363
Identified Species:
37.22
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
T363
S
G
E
M
V
K
S
T
T
S
L
T
S
S
S
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
T363
S
G
E
M
V
K
S
T
T
S
L
T
S
S
S
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
V213
T
L
P
N
A
S
T
V
D
N
I
R
S
I
F
Dog
Lupus familis
XP_534219
757
84567
T363
S
G
E
V
V
K
S
T
T
G
A
T
P
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
T363
S
G
E
A
A
R
P
T
T
G
V
A
S
S
S
Rat
Rattus norvegicus
P97679
757
84522
T363
S
G
E
A
V
K
S
T
T
G
I
A
S
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
A363
S
S
E
V
V
K
S
A
A
S
S
S
T
A
A
Frog
Xenopus laevis
NP_001090545
750
84121
L360
A
S
G
F
T
K
P
L
P
A
S
S
T
S
Q
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
S354
P
G
L
S
A
S
A
S
V
A
K
A
S
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
F342
A
N
S
A
S
R
T
F
Y
L
K
T
R
L
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
S360
I
A
D
D
E
D
K
S
K
G
Q
R
S
S
S
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
T354
N
Q
E
F
I
I
N
T
I
Q
S
A
V
E
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
I363
L
I
P
F
N
D
T
I
E
S
D
R
N
R
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
100
6.6
73.3
N.A.
53.3
73.3
N.A.
N.A.
40
13.3
26.6
N.A.
N.A.
6.6
N.A.
20
P-Site Similarity:
100
100
33.3
80
N.A.
66.6
80
N.A.
N.A.
73.3
40
46.6
N.A.
N.A.
26.6
N.A.
33.3
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
20
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
40
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
0
24
24
0
8
8
8
16
8
31
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
0
16
0
0
8
0
8
0
0
0
0
% D
% Glu:
0
0
54
0
8
0
0
0
8
0
0
0
0
8
0
% E
% Phe:
0
0
0
24
0
0
0
8
0
0
0
0
0
0
8
% F
% Gly:
0
47
8
0
0
0
0
0
0
31
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
8
8
0
8
8
0
16
0
0
8
0
% I
% Lys:
0
0
0
0
0
47
8
0
8
0
16
0
0
0
8
% K
% Leu:
8
8
8
0
0
0
0
8
0
8
16
0
0
8
0
% L
% Met:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
8
0
8
8
0
8
0
0
8
0
0
8
0
0
% N
% Pro:
8
0
16
0
0
0
16
0
8
0
0
0
8
0
8
% P
% Gln:
0
8
0
0
0
0
0
0
0
8
8
0
0
0
8
% Q
% Arg:
0
0
0
0
0
16
0
0
0
0
0
24
8
8
0
% R
% Ser:
47
16
8
8
8
16
39
16
0
31
24
16
54
62
62
% S
% Thr:
8
0
0
0
8
0
24
47
39
0
0
31
16
0
0
% T
% Val:
0
0
0
16
39
0
0
8
8
0
8
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _