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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
15.76
Human Site:
S702
Identified Species:
28.89
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
S702
S
T
L
S
G
Q
Q
S
E
V
P
G
S
I
P
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
S702
S
T
L
S
G
Q
Q
S
E
V
P
G
S
I
P
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
F530
E
M
L
H
N
H
S
F
V
G
C
V
N
P
Q
Dog
Lupus familis
XP_534219
757
84567
S703
S
T
L
S
G
Q
Q
S
E
V
C
G
S
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
S706
S
T
L
S
G
Q
Q
S
D
M
P
G
S
T
S
Rat
Rattus norvegicus
P97679
757
84522
S703
S
A
L
S
G
Q
Q
S
D
M
P
G
S
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
N703
T
N
L
T
R
S
Q
N
E
D
S
D
S
G
P
Frog
Xenopus laevis
NP_001090545
750
84121
D696
D
E
S
S
N
N
A
D
N
K
S
L
T
G
S
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
D671
Y
T
L
E
A
D
A
D
E
P
Q
D
A
E
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
Q662
E
T
A
K
Y
Y
S
Q
I
S
P
V
H
D
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
A691
T
R
G
E
N
D
A
A
S
G
A
D
M
P
S
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
L693
D
E
L
E
H
E
L
L
S
E
A
E
T
A
W
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
D715
S
D
A
S
L
S
E
D
E
K
A
Q
F
I
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
100
6.6
80
N.A.
73.3
66.6
N.A.
N.A.
33.3
6.6
20
N.A.
N.A.
13.3
N.A.
0
P-Site Similarity:
100
100
13.3
80
N.A.
86.6
80
N.A.
N.A.
53.3
13.3
26.6
N.A.
N.A.
13.3
N.A.
13.3
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
6.6
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
20
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
16
0
8
0
24
8
0
0
24
0
8
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% C
% Asp:
16
8
0
0
0
16
0
24
16
8
0
24
0
8
0
% D
% Glu:
16
16
0
24
0
8
8
0
47
8
0
8
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% F
% Gly:
0
0
8
0
39
0
0
0
0
16
0
39
0
16
0
% G
% His:
0
0
0
8
8
8
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
0
0
0
24
0
% I
% Lys:
0
0
0
8
0
0
0
0
0
16
0
0
0
0
0
% K
% Leu:
0
0
70
0
8
0
8
8
0
0
0
8
0
0
0
% L
% Met:
0
8
0
0
0
0
0
0
0
16
0
0
8
0
8
% M
% Asn:
0
8
0
0
24
8
0
8
8
0
0
0
8
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
39
0
0
24
24
% P
% Gln:
0
0
0
0
0
39
47
8
0
0
8
8
0
0
8
% Q
% Arg:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
47
0
8
54
0
16
16
39
16
8
16
0
47
8
31
% S
% Thr:
16
47
0
8
0
0
0
0
0
0
0
0
16
8
8
% T
% Val:
0
0
0
0
0
0
0
0
8
24
0
16
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
8
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _