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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
21.52
Human Site:
S486
Identified Species:
39.44
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
S486
V
E
M
V
E
D
D
S
R
K
E
M
T
A
A
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
S486
V
E
M
V
E
D
D
S
R
K
E
M
T
A
A
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
V326
E
E
S
I
L
E
R
V
Q
Q
H
I
E
S
K
Dog
Lupus familis
XP_534219
757
84567
S487
V
E
M
V
E
D
D
S
R
K
D
M
T
A
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
S490
V
E
M
V
E
N
A
S
G
K
E
M
T
A
A
Rat
Rattus norvegicus
P97679
757
84522
S488
V
E
M
M
E
N
D
S
R
K
E
M
T
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
N487
D
I
Q
M
E
E
D
N
R
K
E
M
T
A
A
Frog
Xenopus laevis
NP_001090545
750
84121
S482
E
M
L
E
D
V
G
S
V
K
T
L
T
A
A
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
A467
V
K
E
D
L
T
A
A
S
L
P
R
R
R
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
S456
T
T
V
A
K
E
K
S
N
S
P
W
S
N
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
D475
R
P
G
P
S
D
E
D
Q
E
L
V
S
R
Q
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
V468
I
S
S
V
Q
E
L
V
N
D
I
D
G
N
C
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
I494
D
E
K
N
A
L
P
I
S
K
D
G
Y
I
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
100
6.6
93.3
N.A.
80
86.6
N.A.
N.A.
60
33.3
6.6
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
46.6
100
N.A.
86.6
100
N.A.
N.A.
80
53.3
20
N.A.
N.A.
33.3
N.A.
40
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
6.6
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
16
8
0
0
0
0
0
54
54
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
16
0
0
8
8
31
39
8
0
8
16
8
0
0
0
% D
% Glu:
16
54
8
8
47
31
8
0
0
8
39
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
8
0
8
0
0
8
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
8
8
0
8
0
0
0
8
0
0
8
8
0
8
16
% I
% Lys:
0
8
8
0
8
0
8
0
0
62
0
0
0
0
8
% K
% Leu:
0
0
8
0
16
8
8
0
0
8
8
8
0
0
0
% L
% Met:
0
8
39
16
0
0
0
0
0
0
0
47
0
0
0
% M
% Asn:
0
0
0
8
0
16
0
8
16
0
0
0
0
16
0
% N
% Pro:
0
8
0
8
0
0
8
0
0
0
16
0
0
0
0
% P
% Gln:
0
0
8
0
8
0
0
0
16
8
0
0
0
0
8
% Q
% Arg:
8
0
0
0
0
0
8
0
39
0
0
8
8
16
8
% R
% Ser:
0
8
16
0
8
0
0
54
16
8
0
0
16
8
0
% S
% Thr:
8
8
0
0
0
8
0
0
0
0
8
0
54
0
0
% T
% Val:
47
0
8
39
0
8
0
16
8
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _