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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
5.15
Human Site:
S467
Identified Species:
9.44
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
S467
E
K
R
G
P
T
S
S
N
P
R
K
R
H
R
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
S467
E
K
R
G
P
T
S
S
N
P
R
K
R
H
R
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
V307
P
Q
N
V
D
V
N
V
H
P
T
K
H
E
V
Dog
Lupus familis
XP_534219
757
84567
G468
K
G
P
P
S
S
P
G
N
P
R
K
R
P
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
G471
A
A
P
T
S
S
P
G
S
S
R
K
R
H
R
Rat
Rattus norvegicus
P97679
757
84522
G469
Q
R
H
P
S
S
P
G
S
S
R
K
R
H
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
K468
S
G
H
L
S
P
E
K
A
L
P
R
K
R
P
Frog
Xenopus laevis
NP_001090545
750
84121
Q463
D
S
P
N
N
I
E
Q
P
R
K
R
P
R
R
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
E448
D
A
Q
P
P
G
D
E
A
P
P
R
K
R
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
I437
L
T
P
N
V
I
D
I
Q
Q
K
D
K
S
M
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
S456
L
C
R
K
R
P
R
S
E
V
S
S
D
T
E
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
V449
L
A
A
V
R
S
S
V
R
Q
R
R
N
P
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
K475
D
Q
P
K
K
K
Q
K
L
G
D
Y
K
V
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
100
13.3
40
N.A.
33.3
26.6
N.A.
N.A.
0
6.6
13.3
N.A.
N.A.
0
N.A.
13.3
P-Site Similarity:
100
100
33.3
53.3
N.A.
46.6
53.3
N.A.
N.A.
13.3
26.6
40
N.A.
N.A.
13.3
N.A.
13.3
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
13.3
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
24
8
0
0
0
0
0
16
0
0
0
0
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
24
0
0
0
8
0
16
0
0
0
8
8
8
0
0
% D
% Glu:
16
0
0
0
0
0
16
8
8
0
0
0
0
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
16
0
16
0
8
0
24
0
8
0
0
0
0
0
% G
% His:
0
0
16
0
0
0
0
0
8
0
0
0
8
31
0
% H
% Ile:
0
0
0
0
0
16
0
8
0
0
0
0
0
0
0
% I
% Lys:
8
16
0
16
8
8
0
16
0
0
16
47
31
0
8
% K
% Leu:
24
0
0
8
0
0
0
0
8
8
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
8
16
8
0
8
0
24
0
0
0
8
0
0
% N
% Pro:
8
0
39
24
24
16
24
0
8
39
16
0
8
16
31
% P
% Gln:
8
16
8
0
0
0
8
8
8
16
0
0
0
0
0
% Q
% Arg:
0
8
24
0
16
0
8
0
8
8
47
31
39
24
39
% R
% Ser:
8
8
0
0
31
31
24
24
16
16
8
8
0
8
0
% S
% Thr:
0
8
0
8
0
16
0
0
0
0
8
0
0
8
0
% T
% Val:
0
0
0
16
8
8
0
16
0
8
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _