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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
8.79
Human Site:
S459
Identified Species:
16.11
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
S459
T
K
G
T
S
E
M
S
E
K
R
G
P
T
S
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
S459
T
K
G
T
S
E
M
S
E
K
R
G
P
T
S
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
S299
L
Y
L
S
L
E
I
S
P
Q
N
V
D
V
N
Dog
Lupus familis
XP_534219
757
84567
K460
G
T
S
E
T
S
E
K
K
G
P
P
S
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
K463
E
T
S
D
A
A
Q
K
A
A
P
T
S
S
P
Rat
Rattus norvegicus
P97679
757
84522
P461
G
A
S
E
V
V
A
P
Q
R
H
P
S
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
K460
V
M
P
G
G
P
S
K
S
G
H
L
S
P
E
Frog
Xenopus laevis
NP_001090545
750
84121
D455
V
L
K
Q
K
K
T
D
D
S
P
N
N
I
E
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
T440
C
G
G
E
D
P
Q
T
D
A
Q
P
P
G
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
C429
K
N
T
D
K
I
Q
C
L
T
P
N
V
I
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
F448
R
K
T
G
P
C
F
F
L
C
R
K
R
P
R
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
S441
D
N
L
E
G
N
S
S
L
A
A
V
R
S
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
K467
T
I
N
D
N
D
L
K
D
Q
P
K
K
K
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
100
13.3
0
N.A.
0
0
N.A.
N.A.
0
0
13.3
N.A.
N.A.
0
N.A.
13.3
P-Site Similarity:
100
100
40
20
N.A.
13.3
20
N.A.
N.A.
0
13.3
33.3
N.A.
N.A.
0
N.A.
13.3
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
13.3
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
20
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
8
8
0
8
24
8
0
0
0
0
% A
% Cys:
8
0
0
0
0
8
0
8
0
8
0
0
0
0
0
% C
% Asp:
8
0
0
24
8
8
0
8
24
0
0
0
8
0
16
% D
% Glu:
8
0
0
31
0
24
8
0
16
0
0
0
0
0
16
% E
% Phe:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% F
% Gly:
16
8
24
16
16
0
0
0
0
16
0
16
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% H
% Ile:
0
8
0
0
0
8
8
0
0
0
0
0
0
16
0
% I
% Lys:
8
24
8
0
16
8
0
31
8
16
0
16
8
8
0
% K
% Leu:
8
8
16
0
8
0
8
0
24
0
0
8
0
0
0
% L
% Met:
0
8
0
0
0
0
16
0
0
0
0
0
0
0
0
% M
% Asn:
0
16
8
0
8
8
0
0
0
0
8
16
8
0
8
% N
% Pro:
0
0
8
0
8
16
0
8
8
0
39
24
24
16
24
% P
% Gln:
0
0
0
8
0
0
24
0
8
16
8
0
0
0
8
% Q
% Arg:
8
0
0
0
0
0
0
0
0
8
24
0
16
0
8
% R
% Ser:
0
0
24
8
16
8
16
31
8
8
0
0
31
31
24
% S
% Thr:
24
16
16
16
8
0
8
8
0
8
0
8
0
16
0
% T
% Val:
16
0
0
0
8
8
0
0
0
0
0
16
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _