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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
4.24
Human Site:
S446
Identified Species:
7.78
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
S446
E
V
A
A
K
N
Q
S
L
E
G
D
T
T
K
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
S446
E
V
T
A
K
N
Q
S
L
E
G
D
T
T
K
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
K286
V
Y
A
A
Y
L
P
K
N
T
H
P
F
L
Y
Dog
Lupus familis
XP_534219
757
84567
E447
A
A
T
N
Q
G
M
E
E
E
T
T
E
G
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
E450
A
A
E
S
E
N
L
E
R
E
S
L
M
E
T
Rat
Rattus norvegicus
P97679
757
84522
E448
A
A
D
S
A
S
L
E
R
E
S
V
I
G
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
D447
A
D
L
I
E
M
A
D
V
Q
Q
D
A
V
M
Frog
Xenopus laevis
NP_001090545
750
84121
A442
L
D
V
L
E
A
T
A
N
S
E
S
Y
V
L
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
A427
D
D
A
E
L
L
T
A
A
D
V
E
P
C
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
H416
Q
Q
K
D
K
S
A
H
V
I
D
N
E
K
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
R435
D
D
G
Q
T
L
P
R
Y
L
K
K
N
R
K
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
L428
A
G
R
L
H
A
Y
L
Q
A
R
P
V
D
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
Q454
L
T
L
N
E
S
E
Q
P
R
D
A
N
T
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
93.3
13.3
6.6
N.A.
13.3
6.6
N.A.
N.A.
6.6
0
6.6
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
93.3
13.3
13.3
N.A.
26.6
20
N.A.
N.A.
26.6
13.3
33.3
N.A.
N.A.
33.3
N.A.
13.3
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
0
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
0
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
39
24
24
24
8
16
16
16
8
8
0
8
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
16
31
8
8
0
0
0
8
0
8
16
24
0
8
0
% D
% Glu:
16
0
8
8
31
0
8
24
8
39
8
8
16
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
0
8
8
0
0
8
0
0
0
0
16
0
0
16
8
% G
% His:
0
0
0
0
8
0
0
8
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
8
0
0
8
0
8
% I
% Lys:
0
0
8
0
24
0
0
8
0
0
8
8
0
8
24
% K
% Leu:
16
0
16
16
8
24
16
8
16
8
0
8
0
8
8
% L
% Met:
0
0
0
0
0
8
8
0
0
0
0
0
8
0
8
% M
% Asn:
0
0
0
16
0
24
0
0
16
0
0
8
16
0
16
% N
% Pro:
0
0
0
0
0
0
16
0
8
0
0
16
8
0
0
% P
% Gln:
8
8
0
8
8
0
16
8
8
8
8
0
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
8
16
8
8
0
0
8
0
% R
% Ser:
0
0
0
16
0
24
0
16
0
8
16
8
0
0
0
% S
% Thr:
0
8
16
0
8
0
16
0
0
8
8
8
16
24
16
% T
% Val:
8
16
8
0
0
0
0
0
16
0
8
8
8
16
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
8
0
8
0
8
0
0
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _