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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH1
All Species:
6.06
Human Site:
S421
Identified Species:
11.11
UniProt:
P40692
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40692
NP_000240.1
756
84601
S421
E
D
K
T
D
I
S
S
G
R
A
R
Q
Q
D
Chimpanzee
Pan troglodytes
XP_001170274
756
84655
S421
E
D
K
T
D
I
S
S
G
R
A
R
Q
Q
D
Rhesus Macaque
Macaca mulatta
XP_001087274
583
64794
S271
H
R
L
V
E
S
T
S
L
R
K
A
I
E
T
Dog
Lupus familis
XP_534219
757
84567
G421
D
R
T
D
V
S
S
G
R
T
G
Q
Q
D
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9JK91
760
84662
G421
V
R
G
A
R
T
E
G
S
P
E
R
A
T
R
Rat
Rattus norvegicus
P97679
757
84522
P421
G
N
R
T
E
G
S
P
E
K
A
M
Q
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418828
757
84832
G421
D
K
V
G
P
P
E
G
T
V
R
P
Q
D
A
Frog
Xenopus laevis
NP_001090545
750
84121
R418
A
E
G
Q
K
H
N
R
V
P
S
E
D
T
K
Zebra Danio
Brachydanio rerio
NP_956953
724
80793
A412
K
T
S
S
T
S
T
A
V
Q
D
S
V
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120100
716
81818
C400
K
N
I
D
K
I
E
C
L
T
S
D
T
I
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793318
745
83320
I418
R
D
V
G
V
V
E
I
L
A
P
A
E
G
M
Poplar Tree
Populus trichocarpa
XP_002325965
747
83627
M412
Q
K
V
P
V
N
K
M
V
R
T
D
A
S
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38920
769
87044
F421
S
S
S
Q
Q
F
N
F
E
G
S
S
T
K
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
76
93
N.A.
88.1
87
N.A.
N.A.
80
75.1
69.7
N.A.
N.A.
50.6
N.A.
60.3
Protein Similarity:
100
99.8
76.5
96.1
N.A.
93.9
93.3
N.A.
N.A.
88.1
85.9
81
N.A.
N.A.
70.7
N.A.
75.7
P-Site Identity:
100
100
13.3
13.3
N.A.
6.6
33.3
N.A.
N.A.
6.6
0
0
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
33.3
33.3
N.A.
6.6
66.6
N.A.
N.A.
13.3
20
40
N.A.
N.A.
33.3
N.A.
20
Percent
Protein Identity:
34.7
N.A.
N.A.
N.A.
36
N.A.
Protein Similarity:
56.6
N.A.
N.A.
N.A.
58.5
N.A.
P-Site Identity:
13.3
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
20
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
0
0
0
8
0
8
24
16
16
0
8
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
16
24
0
16
16
0
0
0
0
0
8
16
8
16
31
% D
% Glu:
16
8
0
0
16
0
31
0
16
0
8
8
8
16
8
% E
% Phe:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% F
% Gly:
8
0
16
16
0
8
0
24
16
8
8
0
0
8
0
% G
% His:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
24
0
8
0
0
0
0
8
8
0
% I
% Lys:
16
16
16
0
16
0
8
0
0
8
8
0
0
16
8
% K
% Leu:
0
0
8
0
0
0
0
0
24
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
8
0
0
8
% M
% Asn:
0
16
0
0
0
8
16
0
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
8
8
8
0
8
0
16
8
8
0
0
0
% P
% Gln:
8
0
0
16
8
0
0
0
0
8
0
8
39
16
0
% Q
% Arg:
8
24
8
0
8
0
0
8
8
31
8
24
0
0
16
% R
% Ser:
8
8
16
8
0
24
31
24
8
0
24
16
0
8
0
% S
% Thr:
0
8
8
24
8
8
16
0
8
16
8
0
16
16
8
% T
% Val:
8
0
24
8
24
8
0
0
24
8
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _